Xylose Health Dictionary

(Roxb.) Blume ex Decne.

Family: Araceae.

Habitat: Native to tropical Asia; cultivated throughout India.

English: Elephant-foot Yam.

Ayurvedic: Suurana, Kanduula, Arshoghna, Kand-ayak, Kandala.

Unani: Zamin-qand, Zamikand.

Siddha/Tamil: Chenaikkizhangu. Kaathukarunai (wild var.)

Action: Corm is prescribed in bronchitis, asthma, abdominal pain, emesis, dysentery, enlargement of spleen, piles, elephantiasis, diseases due to vitiated blood, rheumatic swellings.

Along with other therapeutic applications, The Ayurvedic Pharmacopoeia of India indicates the use of corm in prostatic hyperplasia.

(The corm is irritant due to the presence of calcium oxalate. It can be con- sumedafterit iswashedwell andboiled in tamarind water or butter milk.)

The corm contains an active di- astatic enzyme amylase, betulinic acid, tricontane, lupeol, stigmasterol, beta- sitosterol and its palmitate and glucose, galactose, rhamnose and xylose.

Intake of 3.6-7.2 g of konjac (Amor- phophallus konjac tuber) mannan for 90 days reduced the dose of insulin or hypoglycaemic drugs (in human clinical study). (Francis Brinker.)

Amorphophallus sylvatius Kunth. is equated with the wild var. of Suu- rana, used especially in the treatment of piles.

Dosage: Dried corm—2-10 g powder. (API Vol. III.) 3-5 g powder. (CCRAS.)... amorphophallus campanulatus

Linn.

Family: Asteraceae.

Habitat: Cultivated mainly as an oil-seed crop in Madhya Pradesh, Maharashtra.

English: Safflower.

Ayurvedic: Kusumbha, Vahin- shikhaa, Vastraranjaka, Kusum.

Unani: Qurtum.

Siddha/Tamil: Chendurakam.

Action: Oil—aids prevention of arteriosclerosis, coronary heart disease and kidney disorders as a polyunsaturated fat. Flowers— stimulant, sedative, diuretic, emmenagogue; used in fevers and eruptive skin conditions, measles.

Charred safflower oil is used in rheumatism and for healing sores.

Key application: Dried flowers— in cardiovascular diseases, amen- orrhoea, dysmenorrhoea and retention of lochia; also in wounds and sores with pain and swelling. (Pharmocopoeia of the People's Republic of China, 1997.)

Safflower contains carthamone, lig- nans and a polysaccharide. The polysaccharide, composed of xylose, fructose, galactose, glucose, arabinose, rhamnose and uronic acid residues, stimulates immune function in mice. It induced antibody formation in mice following peritoneal injection. Extracts of flowers have also been tested in China on blood coagulation, where a prolongation of clothing time was observed and platelet aggregation inhibited. Chinese research indicates that Safflower flowers can reduce coronary artery disease, and lower cholesterol levels. Flowers and seeds exhibit lipase activity. The flower extract also exhibited anti-inflammatory, sedative and analgesic effect and inhibitory effect on spontaneous motor activity.

The plant contains a propanetriol derivative, which can be used for the treatment of circulatory disorders.

Recent research suggests that improving the lipid profile might not be as important to reducing the risk of cardiovascular disease as suggested. (Natural Medicines Comprehensive Database, 2007.)

Safflower is contraindicated in pregnancy, gastric disorders, excessive menstruation, haemorrhagic diseases.

Wild and thorny Safflower, growing in the arid tract of Haryana and Punjab (locally known as Kantiaari, Poli, Poiyan) is equated with C. oxy- cantha Bieb. The plant is diuretic. Seed oil is applied topically to ulcers. The plant contains a sesquiterpene gly- coside. Aerial parts contain hinesol- beta-D-fucopyranoside. The plant also contains luteolin-7-glucoside.

Dosage: Leaf—3-6 g powder. (CCRAS.)... carthamus tinctorius

Holostemma ada-kodien

Asclepiadaceae

San: Jivanti;

Hin: Chirvel, Charivel;

Mal: Atapathiyan, Atapotiyan, Atakotiyan;

Tam: Palaikkirai;

Tel: Palagurugu; Mar: Dudurli, Shidodi;

Guj: Kharner, Khiravel

Importance: Holostemma is a twining shrub with large flowers. The roots of Holostemma are useful in ophthalmopathy, orchitis, cough, burning sensation, stomachalgia, constipation, fever and tridoshas. The leaves, flowers and fruits are eaten as vegetable. The root is also used in spermatorrhoea. It is used in preparations of Vidaryadiganam, Dhanwandharam thaila, Manasamithravatakam, Balarishta and Anuthaila. It is also useful in eye diseases and it imparts resistance to diseases.

Distribution: The plant occurs in tropical countries. In India, it is found in Himalayas, Dehradun, Konkan, Bombay, Deccan, Karnataka, Kerala and Tamilnadu. It grows over hedges and in open forests especially on the lower slopes of the hills. It is also distributed in Sri Lanka, Burma and W. China.

Botany: Holostemma ada-kodien Schult. syn. Holostemma annulare (Roxb.) K. Schum.

Holostemma rheedii Wall. belongs to the family Asclepiadaceae. It is a laticiferous twining shrub with large conspicuous flowers. Leaves are simple, opposite and cordate. Flowers are purple, arranged in axillary umbellate cymes. Fruits are thick follicles, 9 cm long, cylindrical and bluntly pointed. The roots are long upto 1 m or more, irregularly twisted, thick and cylindrical. When dry it is yellowish brown to brown black in colour with nearly smooth surface bearing white scars and small depressions. A mature root is about 1-2 cm thick when extracted for use (Warrier et al, 1995).

Agrotechnology: Holostemma prefers a tropical climate. The plant is propagated vegetatively by stem cuttings, but mainly by seeds. The seeds are collected from the plant in November-December before being dispersed. Seeds are cleaned, dried and stored for sowing. The stored seeds after soaking in water for 4-5 hours are sown in the seedbeds. About one month old seedlings are then planted in polybags of size 14x10cm which are filled with soil, sand and dried cowdung in 1:1:1 ratio, respectively. Polybags should be kept in shade and irrigated. About 1-1.5 month old seedlings are ready for transplanting. Pits of 30cm cube size are taken at 1-1.2m distance and filled with 10kg dried cowdung and sand. This is covered with surface soil and formed into a mound. Seedlings are transplanted on to the mounds from the polybags carefully. Regular irrigation is to be given till flowering. To aid in trailing, staking is given one month after planting. Flowering and fruiting occurs in November-December. Harvesting can be done at the end of second year when the vines start drying up. Harvesting is done by digging up the tubers. The tubers are cut into pieces of 10cm length and dried in sun before sale (Prasad et al, 1997).

Properties and activity: Holostemma tubers give -amyrin, lupeol and -sitosterol. Alanine, aspartic acid, glycine, serine, threonine and valine were detected chromatographically (Hussain et al, 1992). The root is antidiabetic, antigonorrhoeic, bechic, alterative, tonic, lactative, ophthalmic, emollient, stimulant, aphrodisiac, expectorant and galactagogue.

BLACH MUSALE Curculigo orchioides Amaryllidaceae

San: Musali;

Hin: Kalimusali, Mushali;

Ben: Talamuli;

Mal: Nilappana;

Guj: Musalikand

Tam: Nilapanai;

Tel: Nelatadi Kelangu;

Kan: Neladali

Importance: Musali is a small, geophilous herb, the tuberous rootstock of which is used as a rejuvenating and aphrodisiac drug. It cures morbid vata and pitta, improves complexion and is useful in general debility, deafness, cough, asthma, piles, skin diseases, impotence, jaundice, urinary disorders, leucorrhoea and menorrhagia (Nadkarni, 1954; Aiyer and Kolammal, 1963; Mooss, 1978). Rootstock is the officinal part and it enters into the Ayurvedic formulations like Vidaryadighrta, Vidaryadi lehya, Marmagulika, Musalyadi churna etc. The Pharmacognosy of C. orchioides has been discussed by Aiyer, Kolamma l (1963), Raghunathan, and Mitra (1982). A bibliographical study on C. orchioides has been done by Pandey et al (1983).

Distribution: The plant is found in all districts of India from near sea level to 2300m altitude, especially in rock crevices and laterite soil. It has been recorded to occur in the sub tropical Himalayas from Kumaon eastwards ascending to 1800m, the Khasia hills, Bengal, Asssam, Konkan, Kanara, the western peninsula and Madras extending south as far as a Cape Comerin. It is also distributed in Sri Lanka, Japan, Malaysia and Australia.

Botany: Curculigo orchioides Gaertn. syn. C. malabarica Wight, C. brevifolia Dryand, Hypoxis dulcis Stand belongs to the family Amaryllidaceae. Musali is a small herbaceous plant with cylindrical rootstock. Leaves are simple, sessile, crowded on the short stem with sheathing leaf bases. Flowers are bright yellow. Seeds are black, deeply grooved in wavy lines.

A detailed description of the plant is as follows (Victoria, 1998). Rootstock is straight, cylindrical, tuberous, 5-22cm long, 0.5-0.8 cm thick, brownish surfaces marked with closely spaced prominent transverse wrinkles in the upper or basal half. It bears a few stout lateral roots of 5 or more cm long. Lateral roots are dull white in colour and spongy externally. The fresh cut surfaces of the rootstock has a starch white colour and mucilaginous. A few fibrous roots also occur. Leaves are sessile or short petiolate with sheathing bases, 15-45x1.2-2.5 cm size, linear or linear lanceolate, membranous, glabrouus or sparsely sofly hairy and plicate in bud. The leaf tips when contacts the soil, develops roots and produce adventitious buds. Inflorescence is axillary, scapose racemose, the scape very short and hidden among the bases of leaves underground, clavte, flattened with the pedicels, bracts and the ovary concealed in the leaf sheaths. The lower big flowers on the scape are mostly bisexual and the upper small ones staminate. Flowers are epigynous bright yellow, bisexual or unisxual with lanceolate, memb ranous bract.. Perianth gamophyllous, rotate & six lobed, locate at the top of a slender sterile long extension of the ovary by means of which the perianth is exposed above the ground. Perianth lobes similar, elliptic oblong 1.2-1.6 cm long, 0.2-0.3 cm broad, outer lobes hairy on the back, inner ones sparsely hairy along nerves. Stamens 6 in number, filamentous filiform, short 2mm long, adnate to the base of the perianth lobes, Anthers linear or linear lanceolate, basifixed and sagittate,.Ovary inferior, hidden among the leaves usually below the ground, tricarpellary syncarpous, lanceolate and trilocular with a fairly long slender beak or extension -the stipe. Ovules many in each cell attached by a distinct long funicle. Style short columnar, 2mm with a 3 lobed stigma. Lobes elongate, erect and appressed. Fruit is a capsule about 1.5-2cm long, 8mm broad, oblong, glabrescent with a slender beak and spongy septa. Seeds 1-many, oblong, black, shiny with crustaceous testa grooved deeply in wavy lines.

Properties and activity: Rao and Beri (1951) have identified glucose, mannose, xylose and glucuronic acid from the rootstock of C. orchioides. The rootstock is also reported to contain glycoside, polysaccharides (hemicellulose and other polysaccharides), starch, resin, tannin, mucilage, fat and calcium oxalate. The hexane extract contains an alkaloid-lycorine, sterols including -sitosterols and sapogenin identified as yuccagenin (Rao et al, 1978). The flavone glycoside from the rootstock has been identified as 5,7- dimethoxy glucopyranoside (Yadav et al, 1974; Sharma et al 1975). Mehta et al (1980) have isolated a number of fatty acids from C. orchioides root oil by GLC techniques. They are palmitic, oleic, linolenic linoleic, arachidic and behenic acid. Kubo et al (1983) isolated a new phenolic glycoside namely, curculigoside from the rhizomes and its structure has been elucidated as 5- hydroxy-2-0- -d-glucopyranosyl benzl 1,2,6-dimethoxy benzoate. Yamasaki et al (1994) developed HPLC method for estimating the curculigoside content in curculigo rhizome.

Two new aliphatic hydroxy ketone 27-hydroxy tricontan-6-one (M. P. 84-85o C) and 23- hydroxy tricontan-2-one (M. P. 109-110 o C) were isolated from the rhizome by Misra et al (1984). They also isolated 21-hydroxy tetracontan-20-one and 4-methyl heptade canoic acid from the root stock. Porwal et al (1988) have isolated and identified three new compounds from the rhizome as N- acetyl-N-hydroxy-2-carbamic acid methyl ester, 3-acetyl-5-carbomethoxy-2H-3,4,5,6-tetrahydro-1,2,3,5,6-oxatetrazine and N, N, N’, N’-tetra methyl succinamide. The rhizomes of C. orchioides yielded a new phenolic glycoside corchioside a, characterised as orcinol-3- -D-xylopyranosyl- (1 6)- -D-glucopyranoside and hentriacontanol (Garg et al, 1989).

A new aliphatic compound has been isolated from the rhizomes and characterised as 25- dihydroxy-33-methyl pentatricontan-one (Mehta et al, 1990). Misra et al (1990) isolated a new natural triterpene alcohol-Curculigol charactrised as 24-methy cycloart-7-en-3-beta-20-diol. A novel pentacyclic triterpene has been isolated from the rhizomes of C.orchioides and characterised as 31- methyl-3-oxo-20-ursen-28-oic acid (Metha and Gawarikar,1991). Xu and Xu (1992) and Xu et al (1992 a, b) have isolated 13 cycloartane type. Triterpene glycosides from C. orchioides rhizome and characterised them as curculigo saponin A-M.

The root stock are mucilaginous, sweet, cooling, bitter, emollient, diuretic, aphrodisiac, depurative, alternative, appetiser, carminative, viriligenic, antipyretic and tonic (Sivarajan and Indira, 1994; Warrier et al, 1994).

The uterine stimulant activity of the flavone glycoside extracted from C. orchioides has been studied by Dhawan and Saxena (1958), Sharma et al (1975) and Dhar et al (1979).

The plant extract of C. orchioides showed hypoglycaemic, spasmolytic and anticancer properties (Dhar et al,1968). Phagocytic activity (Kubo et al, 1983) and immunoadjuvant activity (Oru et al, 1982) of phenolic glycosides, curculigoside isolated from the rhizome of the plant have been reported. Porwal and Mehta (1985) discussed the medicinal importance of the plant and its use in indigenous system of medicine as a tonic. Sharma et al (1991) reported the influence of MAK an ayurvedic food supplement constituting C. orchioides against Dimethyl benz anthracene induced mammary tumours in rats. Samanta (1992) reported the modulation of male infertility by Ayurvedic drug, which constitutes C. orchioides. Immunostimulant activity of C. orchioides has been demonstrated by Saxena (1992). Immunological activites of curculigo saponin G were assayed in mice and the results showed that it promoted proliferation of spleen lymphocyctes very significantly and increased the weight of the thymus in vivo in mice (Xu et al,1992).

Pharmacological studies in China, on the alcoholic extract obtained from the plant showed several active effects such as adaptogenic, anti-inflammatory, anticonvulsant, sedative, androgenic and immunopromoting activities (Xu et al, 1992).

Curculigo orchioides is distributed widely throughout the country. The demand of the raw materials and derivatives of the plant for the indigenous drug industries are satisfied mainly from the wild source, depleting the natural population and thus the species have become extinct or endangered. Ansari (1993) have reported C. orchioides as a threatened plant from Madhulia forest of Garakhpur. Augustin and Souza (1995) also considered the plant as an endangered species. As the information on the cultivation of C.orchioides is scanty, it is very necessary to develop suitable agrotechniques for the domestication and large-scale cultivation of the plant.... holostemma

n. a simple sugar with five carbon atoms: for example, ribose and xylose.... pentose

(Linn.) Lam.

Synonym: Oldenlandia corymbosa Linn.

Family: Rubiaceae.

Habitat: A weed in wet, low lands and in cultivated fields.

Ayurvedic: Kshetraparpata (used in Kerala as Parpataka).

Action: Purifies blood, improves digestion, stimulates action of liver.

The presence of caffeine and fumar- ic acid has been reported in H. corym- bosa.

Iridoidoglucosides have been isolated from H. diffusa Willd. The plant is reported to have immunopotentiation activity and has been used in China to treat some tumours. An aqueous extract of the plant yielded a polysac- charide composed of rhamnose, arabi- nose, xylose, mannose, galactose and glucose.

Hedyotis herbacea Linn., synonym Oldenlandia herbacea Roxb. is also used in Kerala as Parpata, Parpataka.

See Fumaria indica.... hedyotis corymbosa

Linn.

Family: Palmae; Arecaceae.

Habitat: Cultivated in Punjab and Rajasthan.

English: Date Palm.

Ayurvedic: Kharjuura, Kharjuuraka, Kharjuurikaa. Pindakharjuurikaa. Chhuhaaraa (dry date). Pindakhar- juura is the fruit of Phoenix acaulis Roxb.

Unani: Khurmaa, Khajuur, Chhuharaa.

Siddha/Tamil: Perichchankay, Ita.

Action: Fruit pulp—antitussive, expectorant, demulcent, laxative, diuretic, restorative. Sap—cooling, laxative. Gum—used in diarrhoea and genitourinary diseases.

The fruit contains ascorbic acid (vitamin C), carotene (as vitamin A), nicotinic acid, riboflavin, thiamine, sugars (60-80%). Besides sucrose and invert sugars, rhamnose, xylose, ara- binose, ribose, galactose and galac- turonic acid have been identified in the fruit. Invert sugar predominates in the soft dates; sucrose in dry varieties. The dried date, used in Ayurvedic and Unani compositions, contains protein 2.5-3, fat 0.5, carbohydrates 75.882.9% and calcium 35.9, phosphorus 129.3 and iron 3.4 mg/100 g. Presence of sterols of ergosterol group, and esterone has been reported from dried date seeds.

Charged C-glycosylflavones and caf- feylshikimic acid, leucocyanidin are characteristically present in the plant. Flavonol glycosides are also common. Several uncharged C-glycosylflavones were also detected.

Dosage: Fresh fruit—10-50 g, dried fruit—10-15 g. (API, Vol. IV.)... phoenix dactylifera

Trin.

Family: Gramineae; Poaceae.

Habitat: The Himalayas, from Kashmir to Kumaon up to an altitude of 4,000 m.

English: Common Reed.

Folk: Dila, Dambu (Punjab).

Action: Rhizomes and roots—diuretic, emmenagogue, diaphoretic, hypoglycaemic, antiemetic.

The rhizomes are rich in carbohydrates; contain nitrogenous substances 5.2, fat 0.9, N-free extr. 50.8, crude fibre 32.0, sucrose 5.1, reducing sugars 1.1, and ash (rich in silica) 5.8%; as- paragine 0.1% is also present. Leaves possess a high ascorbic acid content (200 mg/100 g).Nodes and sheaths yield 6.6% and the underground parts over 13% of furfural.

The root of common Reed is prescribed in Chinese traditional medicine as an antipyretic against influenza and fevers. Presence of polyols, betaines and free poline has been reported in the methanolic extract. The extract is reported to show bactericidal activity. The root gave a polysaccha- ride which contains sugars, arabinose, xylose and glucose in a molar ratio of 10:19:94; some ofthe fractions showed immunological activity.... phragmites communis

Forsk

Synonym: P. Ispaghula Roxb.

Family: Plantaginaceae.

Habitat: Cultivated In Parts Of Rajasthan And Maharashtra.

English: Ispaghula, Spogel Seeds, Blond Psyllium.

Ayurvedic: Ashvagola. Ashwakarna (Also Equated With Shorea Robusta).

Unani: Aspaghol.

Siddha/Tamil: Isapppa.

Folk: Isabgol.

Action: Seed And Husk—Laxative, Diuretic, Demulcent, Bechic, Cholinergic. Used In Inflammatory Conditions Of The Mucous Membrane Of Gastrointestinal And Genitourinary Tract, Chronic Amoebic And Bacillary Dysentery; Also In Hypercholesterolemia.

Key Application ? In Chronic Constipation And Irritable Bowel. (German Commission E.) Also In Constipation Due To Duodenal Ulcer Or Diverticulitis (Who.) German Commission E Also Noted That Blond Psyllium Seed Lowers Serum Cholesterol Levels. It Has Also Been Shown To Slow Sugar Absorption Thereby Reducing Blood Glucose. (Escop.) Use Of Blond Psyllium Husk Up To Six Months Did Not Clinically Alter Vitamin Or Mineral Status In A Review Of Eight Human Trials. It Did Not Reduce Absorption Of Calcium. (J Am Geriatr Soc, 43, 1995; Am J Clin Nutr, 71, 2000; Natural Medicines Comprehensive Database, 2007.)

The Seed Contains Amino Acids Including Valine, Alanine, Glutamic Acid, Glycine, Cystine, Lysine, Leucine And Tyrosine; And A Mucilage Consisting Of A Mixture Of Polysaccharides Composed Mainly Of Xylose, Arabinose And Galacturonic Acid; Rhamnose And Galactose Are Also Present. The Seeds Also Gave Aucubin, The Antibacterial Principle. The Seed Coat Contains Fatty Acids Mainly Linoleic, Oleic And Palmitic Acids In Decreasing Concentrations.

The Seeds Show A Liver Protective Effect On Induced Hepatotoxicity In Mice. In China, The Plant Is Used Clinically To Treat Certain Types Of Hepatitis (Activity Due To Aucubin Content).

Dosage: Husk—5-10 G. (Ccras.)... plantago ovata

Wall. ex Meissn.

Synonym: R. australe D. Don.

Family: Polygonaceae.

Habitat: Sub-alpine Himalayas, from Kashmir to Sikkim at altitudes of 3,300-5,200 m.; also cultivated in Assam.

English: Indian Rhubarb, Himalayan Rhubarb.

Ayurvedic: Amlaparni, Pitamuuli, Gandhini Revatikaa. Revandachini (roots).

Unani: Revandchini.

Siddha/Tamil: Revalchinikattai, Nattirevaichini.

Action: Purgative, astringent, aperient. Used for constipation and atonic dyspepsia. Not advised for patients suffering from gout, rheumatism, epilepsy. (When given internally, the root imparts a deep tinge to the urine.)

The root gave emodin, emodin- 3-monomethyl ether, chrysophanol, aloe-emodin, rhein. These occur free and as quinone, anthrone or dianthrone glycosides. The astringent principle consists of gallic acid together with small amounts of tannin. The drug also contain cinnamic and rhe- inolic acids, volatile oil, starch and calcium oxalate. Two major glyco- sidic active principles, sennoside A and B, are present along with free an- thraquinones.

At low doses, the tannin exerts astringent effect and relieves diarrhoea; at higher doses anthraquinones stimulate laxative effect and relieve constipation. (Natural Medicines Comprehensive Database, 2007.)

There are three main types of rhubarbs—Chinese, Indian or Himalayan, and Rhapontic.

The Chinese rhubarb consists of the rhizomes and roots of Rheum palma- tum and R. officinale.

The Indian rhubarb consists of dried rhizomes of R. emodi and R. web- bianum; rhizomes and roots of R. moorcroftianum and R. spiciforme are also reported to be mixed with the drug. R. rhaponticum is the Rhapontic rhubarb.

Rheum moorcroftianum Royle (the Himalayas at altitudes of 3,0005,200 m., chiefly in Garhwal and Ku- maon) possesses properties similar to those of R. emodi and the roots are mixed with the latter.

Rheum spiciforme Royle (drier ranges of Kumaon and Sikkim at altitudes of 2,700-4,800 m.) also possesses purgative properties. The rhizomes and roots are mixed up with Himalayan rhubarb.

Rheum webbianum Royle (the western and central Himalayas at altitudes of 3,000-5,000 m.) is the source of Himalayan rhubarb.

Rheum palmatum is esteemed as the best type of (Chinese) rhubarb. Two new stilbene glycosides, 4'-O- methylpiceid and rhapontin, isolated from the roots, exhibited moderate alpha-glucosidase inhibitory activity. Anthraquinone glucoside, pul- matin, isolated from the roots, along with its congeners, chrysophanein and physcionin, showed cytotoxic activity against several types of carcinoma cells. Polysaccharides, isolated from the roots and rhizomes, contained lyx- ose, glucose, galactose, xylose, rham- nose, mannose and ribose.

Dosage: Root—0.2-1.0 g powder. (CCRAS.)... rheum emodi

Roxb.

Synonym: S. sara Roxb. S. bengalense Retz. Erianthus munja Jesw.

Family: Gramineae; Poaceae.

Habitat: Throughout the plains and low hills of India.

Ayurvedic: Munja, Bhadramuja, Vaana, Shara, Sara, Raamshara.

Siddha/Tamil: Munjipul, Munjap- pullu.

Folk: Sarpata.

Action: Refrigerant. Useful in burning sensation, thirst, dyscrasia, erysipelas and urinary complaints.

The Ayurvedic Pharmacopoeia of India recommends the use of the root in dysuria, giddiness and vertigo.

The stem is a good source of furfural (yield 5.67%, dry basis). It yields 19.5% (on dry weight) of reducing sugars when digested with sulphuric acid; glucose, xylose, galactose and rhamnose have been identified in the hydrolysate which contains 34.5% fermentable sugars. (It can be used as a potential source of alcohol.)

In Kerala, Saccharum arundinaceum Retz. is used as Shara for dysuria, diseases due to vitiated blood, erysipelas, leucorrhoea and piles. The grass is known as Raamshara in North India. It can also be used for the production of furfural (yield 5.1% dry basis) and yields 24.1% of reducing sugars when digested with sulphuric acid. The hy- drolysate contains 65% of fermentable sugars, viz. glucose, xylose, galactose and rhamnose.

Dosage: Root—20-50 g for decoction; 6-10 g powder. (API, Vol. III.)... saccharum munja

Schott.

Family: Araceae.

Habitat: Tropical Himalayas, Bengal, southwards to Andhra Pradesh and the Andamans.

Ayurvedic: Gajakrishna, Hastipip- pali, Gajapippali (also equated with Piper chaba).

Siddha/Tamil: Anaitippili.

Action: Fruits—stimulant, carminative, diaphoretic, anthelmintic, antidiarrhoeal. Decoction is used as an expectorant in asthma. Fruits and shoots—hypoglycaemic. Fruit pulp—applied externally in rheumatism.

The Ayurvedic Pharmacopoeia of India recommends dried pieces of mature female spadix in dyspnoea. (Gajapip- pali is wrongly equated with male or female inflorescence of Borassus flabel- lifer Linn.)

The fruits contain two glycosidic substances—scindapsin A and B, which on hydrolysis yield the aglu- cons, scindapsinidine A and B. Free sugars, rhamnose, fructose, glucose and xylose together with some di-and trisaccharides have been identified in the plant.

Dosage: Dried pieces of mature female spadix—2-3 g for infusion. (API, Vol. II.)... scindapsus officinalis

Linn.

Synonym: T. occidentalis Gaertn. T. officinalis HK.

Family: Caesalpiniaceae.

Habitat: Indigenous to tropical Africa; now distributed throughout the plains and sub-Himalayan tracts of India.

English: Tamarind tree.

Ayurvedic: Amli, Amlikaa, Suktaa, Chukraa, Chukrikaa, Chinchaa, Chandikaa, Tintidika.

Unani: Tamar Hindi

Siddha/Tamil: Puli, Aanvilam.

Action: Pulp of fruit—cooling, digestive, carminative, laxative, antiscorbutic; infusion prescribed in febrile diseases and bilious disorders; used as a gargle in sore throat; applied as a poultice on inflammatory swellings.

The Ayurvedic Pharmacopoeia of India recommends the fruit pulp in tiredness without exertion.

Leaves—juice, used for bleeding piles, bilious fever and dysuria. Stem- bark—antipyretic and astringent.

Used for diarrhoea. Bark is also prescribed in asthma and amenor- rhoea. Seed-kernel—stimulant; used as a supporting tonic in sexual debility in Unani medicine.

Water stored in the tumbler, made out of the wood, is given for treating splenic enlargement.

Ethanolic extract of the seed coat exhibited antioxidant activity. Kernel gave polysaccharides composed of D- glucose, D-xylose, D-galactose and L- arabinose in a molar ratio of 8:4:2:1. Polysaccharides showed immunomod- ulatory activities such as phagocytic enhancement, leukocyte migration inhibition and inhibition of lymphocyte proliferation.

The leaves gave flavone C-glycosi- des—orientin, vitexin, iso-orientin and iso-vitexin. The leaves and fruits gave tartaric acid and malic acid. The fruit pulp yielded amino acids—ser- ine, beta-alanine, proline, pipecolinic acid, phenylalanine and leucine.

A bitter principle, tamarindienal, isolated from the fruit pulp, showed fungicidal and bactericidal activity against Aspergillus nigar, Candida al- bicans, Bacillus subtilis, Staphylococcus aureus, E. coli and Pseudomonas aerug- inosa.

The ash of the bark is given in colic and indigestion. The ash is also used in gargles and mouthwash for apthous sores.

Dosage: Fruit pulp without seeds— 4-10 g. (API, Vol. IV.)... tamarindus indica

Linn.

Family: Compositae; Asteraceae.

Habitat: Western Himalayas from Kashmir to Nepal at 1,500-3,500 m.

English: Coughwort, Coltsfoot, Asses' Foot.

Unani: Fanjiyun.

Action: Leaves and flowers— anticatarrhal, antitussive, expectorant, antispasmodic, demulcent, anti-inflammatory. Used for dry, unproductive, irritative cough, smoker's cough, whooping cough, bronchial asthma (effect shortlived), laryngitis.

Key application: In acute catarrh of the respiratory tract with cough and hoarseness; acute, mild inflammation of the oral and pharyngeal mucosa. Contraindicated during pregnancy and nursing. (German Commission E.)

The leaves and flowers contain flavo- noids including rutin, hyperoside and isoquercetin; pyrrolizidine alkaloids including senkirkine and tussilagine (about 0.015%); mucilage (about 8%) consisting of polysaccharides based on glucose, galactose, fructose, arabinose and xylose; inulin, tannins.

Polysaccharides are antiinflammatory and immuno-stimulating, as well as demulcent. Flavonoids also have anti-inflammatory and antispasmod- ic action. Pyrrolizidine alkaloids have caused hepatotoxicity in rats fed daily on high doses, but not on daily low dose regimes. These are largely destroyed when the herb is boiled.

The leaf contains an inhibitor of platelet activating factor (PAF). The PAF inhibitor can account for Coltsfoot's efficacy in asthma. The constituent, tussilagone has respiratory stimulant and cardiovascular (including pressor) activities. In animal studies, Coltsfoot is reported to have a pres- soreffect similartodopaminebut without tachyphylasis. (Natural Medicines Comprehensive Database, 2007.)... tussilago farfara

Strychnos nux-vomica

Loganiaceae

San: Karaskara;

Hin: Kajra, Kuchila;

Mal: Kanjiram; ;

Tam: Itti, Kagodi, Kanjirai Mar:Jharkhatchura;

Kan: Hemmushti, Ittangi;

Tel: Mushti, Mushidi; Ori: Kora, Kachila

Importance: It is a large deciduous tree, with simple leaves and white fragrant flowers.

Strychnos is highly toxic to man and animals producing stiffness of muscles and convulsions, ultimately leading to death. However, in small doses it can also serve as efficacious cure forms of paralysis and other nervous disorders. The seeds are used as a remedy in intermittent fever, dyspepsia, chronic dysentery, paralytic and neuralgic affections, worms, epilepsy, chronic rheumatism, insomnia and colic. It is also useful in impotence, neuralgia of face, heart disease, spermatorrhoea, skin diseases, toxins, wounds, emaciation, cough and cholera. Leaves are applied as poultice in the treatment of chronic wounds and ulcers and the leaf decoction is useful in paralytic complaints. Root and root bark used in fever and dysentery (Nadkarni, 1982; Kurup et al, 1979).

Distribution: The plant is distributed throughout India in deciduous forests up to 1200m. It is also found in Sri Lanka, Siam, Indochina and Malaysia.

Botany: Strychnos nux-vomica Linn. is a large tree belonging to the family Loganiaceae. Leaves are simple, opposite, orbicular to ovate, 6-11.5x6-9.5cm, coriaceous, glabrous, 5 nerved, apex obtuse, acute or apiculate, transverse nerves irregular and inconspicuous. Inflorescence is many flowered terminal cymes, 2.5-5cm across. Bracts (5mm) and bracteoles (1.5mm) small. Flowers are white or greenish white and fragrant. Calyx 5 lobed, pubescent and small (2mm). Corolla salver shaped, tube cylindrical slightly hairy near the base within and greenish white, tube much elongate than the lobes. Tube 7mm and lobes 2.5mm long. Lobes 5 and valvate. Stamens 5, filaments short, 0.1mm long. Anthers 1.5mm subexerted, linear oblong. Ovary 1.5 mm, pubescent, 2 celled, ovules one to many. Style 9mm, stigma capitate. Fruit is a berry, 5-6cm diameter, globose, indehiscent, thick shelled, orange red when ripe with fleshy pulp enclosing the seeds. Seeds 1-many, discoid, compressed, coin like, concave on one side and convex on the other, covered with fine grey silky hairs.

The leaf fall is during December (do not shed all the leaves at a time) and new foliage appears in February. Flowering is during March - April and fruiting during May - December. Fruits take about 8-9 months to mature.

Properties and activity: Strychnine and brucine are the most important and toxic alkaloids present in the plant. They occur not only in the seeds but also in roots, wood, bark, fruit pulp and hard fruit shells. The minor alkaloids present in the plant are vomicine, -colubrine, -colubrine, pseudostrychnine and N-methyl-sec-pseudobrucine (novacine). Loganin a glycoside is also present (Warnat, 1932; Martin et al, 1953; Guggisberg et al, 1966; Bisset and Chaudhary, 1974). Chatterji and Basa (1967) reported vomicine as the major constituent alkaloid along with unidentified alkaloid in leaves and identified another alkaloid kajine (N-methyl pseudostrychnine) from the leaves of very young plants.

Root bark of S. nux-vomica yeilded 4-hydroxy-3-methoxy strychnine, 4 hydroxy strychine, nor-macusine, a new alkaloid 12 , 13 dihydro-12 -hydroxy isostrychnine named protostrychnine (Baser et al, 1979) methoxy strychnine, and mavacurine (Guggisberg et al, 1966). Leaves and root bark also yeilded 11 new alkaloids. 10-hydroxy strychnine, 3-12-dihydroxystrychnine, 12-hydroxy–11- methoxy strychnine, 3-12-dihydroxy- 11-methoxy strychnine,12-hydroxy strychnine-N- oxide 12-hydroxy-11-methoxy strychnine- N-oxide-19,20–dihydro isostrychnine, 16 , 17 dihydro-17 -hydroxy isostrychnine, O- methyl-macusine B, 16-epi-o-methyl–macusine B and normelinone B (Baser and Bisset, 1982).

De and Datta (1988) isolated 5 tertiary indole alkaloids viz. strychnine, brucine, vomicine, icajine and novacine from S.nux-vomica flowers. Bisset et al (1989) isolated and identified two phenolic glycosides salidroside and cuchiloside – a compound consisting of salidroside and an attached xylose unit, from the fruit of S.nux-vomica.

Rodriguez et al (1979) isolated an indole alkaloid from the seeds of S. nux- vomica and identified as a 3-methoxy icajine. A new alkaloid 15-hydroxy strychnine has been isolated from the seeds and the structure of the alkaloid established by spectroscopic data (Galeffi et al, 1979). Cai et al (1990a) isolated 4 new alkaloids isobrucine, isobrucine N-oxide, isostrychnine N-oxide and 2 hydroxy–3-methoxy strychnine from the heat treated seeds of S. nuxvomica and the structure of the alkaloids were determined by 13 CNMR (Cai et al, 1994). Cai et al (1990 b) studied the changes in the alkaloid composition of the seeds during drug processing. Saily et al (1994) determined the mineral elements in Strychnos nux-vomica. Corsaro et al (1995) reported polysaccharides from the seeds of Strychnos species.

Seeger and Neumann (1986) reviewed the physico-chemical characteristics, occurrence, identification, utilisation, poisoning, toxicity, kinetics, differential diagnosis and therapeutic uses of strychnine and brucine. Aspergillus niger, A. flavus and Pencillium citrinum showed regular association with Strychnos seeds and effectively deteriorated the alkaloid content of the seeds (Dutta, 1988; Dutta and Roy, 1992). Nicholson (1993) described the history, structure and synthesis of strychnine which occur in the seeds of S. nux-vomica. Rawal and Michoud (1991) developed a general solution for the synthesis of 2- azabicyclo (3.3.1) nonane substructure of Strychnos alkaloids.

Villar et al (1984) and Hayakawa et al (1984) developed HPLC method for the analysis of strychnine and brucine. Graf and Wittliner (1985), Kostennikova (1986) and Gaitonde and Joshi (1986) suggested different methods for the assay of strychnine and brucine. Biala et al, (1996) developed new method for the assay of alkaloids in S. nux- vomica.

The seeds are bitter, acrid, alexeteric, aphrodisiac, appetiser, antiperiodic, anthelmintic, digestive, febrifuge, emmenagogue, purgative, spinal, respiratory and cardiac stimulant and stomachic. The bark is bitter, and tonic and febrifuge (Nadkarni, 1954; Kurup et al, 1979; Warrier et al, 1996).

The quarternery alkaloid from the root bark of the Sri Lankan plant exhibited muscle-relaxant activity (Baser and Bisset, 1982). Antimicrobial activity of indole alkaloid isolated from the Strychnos nux-vomica was studied by Verpoorte et al, 1983. Shukla et al (1985) evaluated the efficacy of Rasnadigugglu compound consisting of S. nux-vomica, on rheumatoid arthritis and found to be effective in reducing inflammatory oedoma and rheumatoid arthritis. It also exhibited analgesic activity. A compound Unani formulation containing S. nux-vomica significantly attenuated withdrawal intensity in morphine dependent rats (Zatar et al, 1991). Shahana et al (1994) studied the effect of Unani drug combination (UDC) having Strychnos nux-vomica on the abstinence syndrome in moderately and severely morphine dependent rats. The UDC strikingly suppressed the abstinence syndrome was seen to possess central depressant and analgesic action.

Melone et al (1992) reported brucine-lethality in mice. Panda and Panda (1993) and Satyanarayanan et al (1994) reported antigastric ulcer activity of nux vomica in Shay rats. Banerjee and Pal (1994) reported the medicinal plants used by the tribals of plain land in India for hair and scalp preparation and S. nux-vomica being used to cure alopecia (baldness) by the tribals. Tripathi and Chaurasia (1996) studied the effect of S. nux-vomica alcohol extract on lipid peroxidation in rat liver.... strychnine tree

Linn.

Family: Hydrocharitaceae.

Habitat: Hydrophyte; throughout India.

English: Eel-Grass, Tape Grass, Wild Celery.

Ayurvedic: Shaivala, Shaivaala. (Ceratophyllum demersum Linn. is also equated with Shaivala.)

Folk: Sevaar.

Action: Plant—stomachic, refrigerant, demulcent. Also used in leucorrhoea and spermatorrhoea.

Extracts of the plant yielded polysaccharides containing D-galactose, D-xylose, L-arabinose, L-rhamnose, uronic acid, acidic xylan and an arabi- no galactan.... vallisneria spiralis

Kunth.

Family: Hydrophyllaceae.

Habitat: Native to tropical America; introduced into Indian gardens.

Action: Leaves and branch tips— a decoction is used in rheumatism; also for whooping cough and respiratory problems.

Solvent extracts of the leaves (etha- nol, acetone and M-hexane) were found active against Gram-positive bacteria.

Synonym: W. viridiflora Meissn. W. indica var. virdiflora Hook. f.

Family: Thymelaeaceae.

Habitat: Eastern Assam; as a weed in Tamil Nadu.

English: Small-Leaf Salago.

Folk: Salago.

Action: Root bark—diuretic, vesicant, purgative and piscicidal.

The root bark is reported to contain a flavone glycoside, wikstroemin, which exhibited diuretic activity.

In Chinese folk medicine, the bark is used for schistosomiasis.

The stem contains wikstromol, a lig- nin prototype which exhibited anti- neoplastic activity. Daphnoretin, isolated from the plant, caused platelet aggregation in the blood of rabbits. A polysaccharide, comprising glucose, arabinose, galacturonic acid, galactose and xylose, protected mice against radiation and enhanced the formation of macrophages.... wigandia caracasana