Habitat: Kashmir, Himachal Pradesh, Tehri-Garhwal and other areas of northern India, at altitudes of 2,100-3,600 m.
English: Pindrow-Fir, Silver-Fir, The West-Himalayan Low-Level Fir.Ayurvedic: Taalisha (related sp.).Folk: Badar, Morinda, Raisalla, Ransla.Action: Uses similar to those of A. webbiana.
Terpenoids, flavonoids, glycosides and steroids of the leaf were found to have mast cell stabilizing action in rats. Terpenoids and flavonoids offered bronchoprotection against his- tamine challenge in guinea pigs. The ulcer protective action of petroleum ether, benzene and chloroform fraction has been attributed to steroidal contents. Terephthalic acid demethyl ester (TADE), isolated from the leaf, exhibited protection against inflammation and bronchospasm in guinea pigs. Ethanolic extract of leaves showed significant anxiolytic effects on all the paradigms of anxiety, barbiturate hypnosis potentiation.Pindrolactone, a lanostane-based triterpene lactone, isolated from the leaves, showed mild activity against Gram-positive bacteria but exhibited potent antibacterial activity against Gram-negative bacteria E. coli.... abies pindrowHabitat: Throughout India, especially common in Kumaon Hills and the Nilgiris, below an altitude of 1,200 m.
English: Peacocks tail.Ayurvedic: Mayurshikhaa, Madhu- chhadaa, Sahastrahi, Vahrishikhaa.Action: Styptic, antibacterial, antipyretic.
The stems and leaves contain rutin, a styptic active principle. Anthelmintic activity, attributed to the fern, was not observed in experiments on mice.Dosage: Root—3-5 g powder. (CCRAS.)... actiniopteris dichotomaThe effects of ageing include: cessation of MENSTRUATION in females; wrinkling of the skin due to a loss of elastic tissue; failing memory (especially short term) and a reduced ability to learn new skills, along with slowed responses
– changes caused by the loss of or less e?cient working of nerve cells; the senses become less acute; the lungs become less e?cient, as does heart muscle, both causing a fall in exercise tolerance; arteries harden, resulting in a rise in blood pressure and poor blood circulation; joints are less mobile, bones beome more brittle (OSTEOPOROSIS) and muscle bulk and strength are reduced; the lens of the EYE becomes less elastic, resulting in poorer sight, and it may also become opaque (CATARACT).
In developed countries people are living longer, in part because infant and child mortality rates have dropped dramatically over the past 100 years or so. Improved standards of living and more e?ective health care have also contributed to greater longevity: the proportion of people over 65 years of age has greatly increased, and that of the over-75s is still rising. The 2001 census found 336,000 people in the UK aged over 90 and there are 36,000 centenarians in the US. This extreme longevity is attributed to a particular gene (see GENES) slowing the ageing process. Interestingly, those living to 100 often retain the mental faculties of people in their 60s, and examination of centenarians’ brains show that these are similar to those of 60-year-olds. (See MEDICINE OF AGEING; CLIMACTERIC.)
Help and advice can be obtained from Age
Concern and Help the Aged. See www.helpthaged.org.uk www.ageconcern.org.uk... ageing
Cancers are classi?ed according to the type of cell from which they are derived as well as the organ of origin. Hence cancers arising within the bronchi, often collectively referred to as ‘lung cancer’, include both adenocarcinomas, derived from epithelium (surface tissue), and carcinomas from glandular tissue. Sarcomas are cancers of connective tissue, including bone and cartilage. The behaviour of cancers and their response to therapy vary widely depending on this classi?cation as well as on numerous other factors such as how large the cancer is, how fast the cells grow and how well de?ned they are. It is entirely wrong to see cancer as a single disease entity with a universally poor prognosis. For example, fewer than one-half of women in whom breast cancer (see BREASTS, DISEASES OF) is discovered will die from the disease, and 75 per cent of children with lymphoblastic LEUKAEMIA can be cured.
Incidence In most western countries, cancer is the second most important cause of death after heart disease and accounts for 20–25 per cent of all deaths. In the United Kingdom in 2003, more than 154,000 people died of malignant disease. There is wide international variation in the most frequently encountered types of cancer, re?ecting the importance of environmental factors in the development of cancer. In the UK as well as the US, carcinoma of the BRONCHUS is the most common. Since it is usually inoperable at the time of diagnosis, it is even more strikingly the leading cause of cancer deaths. In women, breast cancer was for a long time the most common malignant disease, accounting for a quarter of all cancers, but ?gures for the late 1990s show that lung cancer now heads the incidence list – presumably the consequence of a rising incidence of smoking among young women. Other common sites are as follows: males – colon and rectum, prostate and bladder; females – colon and rectum, uterus, ovary and pancreas.
In 2003, of the more than 154,000 people in the UK who died of cancer, over 33,000 had the disease in their respiratory system, nearly 13,000 in the breast, over 5,800 in the stomach and more than 2,000 in the uterus or cervix, while over 4,000 people had leukaemia. The incidence of cancer varies with age; the older a person is, the more likely it is that he or she will develop the disease. The over-85s have an incidence about nine times greater than those in the 25–44 age group. There are also di?erences in incidence between sexes: for example, more men than women develop lung cancer, though the incidence in women is rising as the effects of smoking work through. The death rate from cancer is falling in people under 75 in the UK, a trend largely determined by the cancers which cause the most deaths: lung, breast, colorectal, stomach and prostate.
Causes In most cases the causes of cancer remain unknown, though a family history of cancer may be relevant. Rapid advances have, however, been made in the past two decades in understanding the di?erences between cancer cells and normal cells at the genetic level. It is now widely accepted that cancer results from acquired changes in the genetic make-up of a particular cell or group of cells which ultimately lead to a failure of the normal mechanisms regulating their growth. It appears that in most cases a cascade of changes is required for cells to behave in a truly malignant fashion; the critical changes affect speci?c key GENES, known as oncogenes, which are involved in growth regulation. (See APOPTOSIS.)
Since small genetic errors occur within cells at all times – most but not all of which are repaired – it follows that some cancers may develop as a result of an accumulation of random changes which cannot be attributed to environmental or other causes. The environmental factors known to cause cancer, such as radiation and chemicals (including tar from tobacco, asbestos, etc.), do so by increasing the overall rate of acquired genetic damage. Certain viral infections can induce speci?c cancers (e.g. HEPATITIS B VIRUS and HEPATOMA, EPSTEIN BARR VIRUS and LYMPHOMA) probably by inducing alterations in speci?c genes. HORMONES may also be a factor in the development of certain cancers such as those of the prostate and breast. Where there is a particular family tendency to certain types of cancer, it now appears that one or more of the critical genetic abnormalities required for development of that cancer may have been inherited. Where environmental factors such as tobacco smoking or asbestos are known to cause cancer, then health education and preventive measures can reduce the incidence of the relevant cancer. Cancer can also affect the white cells in the blood and is called LEUKAEMIA.
Treatment Many cancers can be cured by surgical removal if they are detected early, before there has been spread of signi?cant numbers of tumour cells to distant sites. Important within this group are breast, colon and skin cancer (melanoma). The probability of early detection of certain cancers can be increased by screening programmes in which (ideally) all people at particular risk of development of such cancers are examined at regular intervals. Routine screening for CERVICAL CANCER and breast cancer (see BREASTS, DISEASES OF) is currently practised in the UK. The e?ectiveness of screening people for cancer is, however, controversial. Apart from questions surrounding the reliability of screening tests, they undoubtedly create anxieties among the subjects being screened.
If complete surgical removal of the tumour is not possible because of its location or because spread from the primary site has occurred, an operation may nevertheless be helpful to relieve symptoms (e.g. pain) and to reduce the bulk of the tumour remaining to be dealt with by alternative means such as RADIOTHERAPY or CHEMOTHERAPY. In some cases radiotherapy is preferable to surgery and may be curative, for example, in the management of tumours of the larynx or of the uterine cervix. Certain tumours are highly sensitive to chemotherapy and may be cured by the use of chemotherapeutic drugs alone. These include testicular tumours, LEUKAEMIA, LYMPHOMA and a variety of tumours occurring in childhood. These tend to be rapidly growing tumours composed of primitive cells which are much more vulnerable to the toxic effects of the chemotherapeutic agents than the normal cells within the body.
Unfortunately neither radiotherapy nor currently available chemotherapy provides a curative option for the majority of common cancers if surgical excision is not feasible. New e?ective treatments in these conditions are urgently needed. Nevertheless the rapidly increasing knowledge of cancer biology will almost certainly lead to novel therapeutic approaches – including probably genetic techniques utilising the recent discoveries of oncogenes (genes that can cause cancer). Where cure is not possible, there often remains much that can be done for the cancer-sufferer in terms of control of unpleasant symptoms such as pain. Many of the most important recent advances in cancer care relate to such ‘palliative’ treatment, and include the establishment in the UK of palliative care hospices.
Families and patients can obtain valuable help and advice from Marie Curie Cancer Care, Cancer Relief Macmillan Fund, or the British Association of Cancer United Patients.
www.cancerbacup.org.uk
www.mariecurie.org.uk... cancer
Habitat: Cultivated as an annual all over the country. The most important onion-growing states are Maharashtra, Tamil Nadu, Andhra Pradesh., Karnataka and Madhya Pradesh.
English: Onion.Ayurvedic: Palaandu, Durgandh.Unani: Piyaaz.Siddha/Tamil: Venkaayam.Action: Antibiotic, antibacterial, antisclerotic, anticoagulant, anti-inflammatory, antiasthmatic, expectorant, carminative, anti- spasmodic, diuretic, hypotensive, antidiabetic.
Key application: For the prevention of atherosclerosis (German Commission E) and age-dependent changes in the blood vessels, and loss of appetite (WHO).The official onion bulb of the Pharmacopoeia of the People's Republic of China is a different species, Allium macrostemon Bge., than that of the German Commission E monographs, A. cepa. Chinese onion is used for cough, dyspnoea, angina pectoris and dysentery.Scallions or Spring Onion of Chinese medicine are equated with Allium fistulosum.Onion bulbs contain a volatile oil with sulphurous constituents, including allylpropyldisulphide; sulphur- containing compounds, including al- licin, alliin; flavonoids; phenolic acids and sterols.Hypoglycaemic activity of the onion is attributed to the allylpropyldisul- phide and allicin. Diphenylamine, isolated from mature bulbs, also exhibits potent antihyperglycaemic activity.Alliin and allicin have an inhibitory effect on platelet aggregation. Antibiotic activity is due mainly to alli-cin.Regular use of onion (50 g/day) reduces insulin requirement of a diabetic patient from 40 to 20 units a day.Thiosulphinates, isolated from onion juice, exhibited antiasthmatic activity in vivo.Dosage: Juice of bulb—10-20 ml. (CCRAS.)... allium cepaHabitat: Native to Central Asia. Cultivated all over India.
English: Garlic.Ayurvedic: Lashuna, Rasona, Yavaneshta, Ugragandha, Ma- haushadh, Arishta.Unani: Seer, Lahsun.Siddha/Tamil: Ullippoondu, Vellaip- pondu.Action: Antibiotic, bacteriostatic, fungicide, anthelmintic, antithrom- bic, hypotensive, hypoglycaemic, hypocholesterolaemic. Also used for upper respiratory tract infections and catarrhal conditions.
Key application: As a supportive to dietary measures for elevated levels of lipids in blood; as a preventive measure for age-dependent vascular changes. (German Commission E, ESCOP, WHO, The British Herbal Pharmacopoeia.) Also as an antimicrobial. (The British Herbal Pharmacopoeia). Garlic has been shown to be effective in respiratory infections and catarrhal conditions. (The British Herbal Compendium.)The Ayurvedic Pharmacopoeia ofIn- dia indicates the use of the bulb as a brain tonic in epilepsy and psychic disorders.Heavy consumption of garlic prior to surgery led to increased clotting time or reduced platelet aggregation (in human case reports). Garlic tablets at a dose of 400 mg twice daily for 12 weeks reduced platelet aggregation 59% compared with placebo in 80 patients (in human clinical study). (Francis Brinker.)Garlic cloves are high in sulphur- containing amino acids known as al- liin (no taste, no smell, no medicinal action). With crushing or chewing alli- in comes into contact with the enzyme alliinase. Alliinase, in less than 6 s, transforms alliin into allicin (strongly medicinal), which breaks down into a number of sulphur compounds including ajoene, vinyldithin and diallyl disulfide, and trisulfide. The antibiotic effect is attributed to allicin; hypogly- caemic effect to allicin and allylpro- phyldisulphide (also to S-allyl cysteine sulfoxide); anticarcinogenic activity to diallyl monosulfide; platelet aggregation inhibitory effect to diallyl-di- and tri-sulphides. Ajoene inactivated human gastric lipase, which is involved in digestion and absorption of dietary fats.Diallyltetra, penta-, hexa- and hep- tasulphides are potential antioxidants.Allium leptophyllum Wall. is equated with Vana Lashuna, Jangali Lahsun.Dosage: Bulb—3 g (API Vol. III.)... allium sativumNutritional Profile Energy value (calories per serving): Low Protein: Low Fat: Low Saturated fat: Low Cholesterol: None Carbohydrates: High Fiber: Moderate Sodium: Low Major vitamin contribution: Vitamin A, vitamin C Major mineral contribution: Potassium
About the Nutrients in This Food Grapefruit and ugli fruit (a cross between the grapefruit and the tangerine) have moderate amounts of dietary fiber and, like all citrus fruits, are most prized for their vitamin C. Pink or red grapefruits have moderate amounts of vitamin A. One-half medium (four-inch diameter) pink grapefruit has 1.4 g dietary fiber, 1,187 IU vitamin A (51 percent of the R DA for a woman, 40 percent of the R DA for a man), and 44 mg vitamin C (59 percent of the R DA for a woman, 49 percent of the R DA for a man). One half medium (3.75-inch diameter) white grapefruit has 1.3 g dietary fiber, 39 IU vitamin A (2 percent of the R DA for a woman, 1 percent of the R DA for a man), and 39 mg vitamin C (52 percent of the R DA for a woman, 43 percent of the R DA for a man). Pink and red grapefruits also contain lycopene, a red carotenoid (plant pigment), a strong antioxidant that appears to lower the risk of cancer of the prostate. The richest source of lycopene is cooked tom atoes.
The Most Nutritious Way to Serve This Food Fresh fruit or fresh-squeezed juice.
Buying This Food Look for: Firm fruit that is heavy for its size, which means that it will be juicy. The skin should be thin, smooth, and fine-grained. Most grapefruit have yellow skin that, depending on the variety, may be tinged with red or green. In fact, a slight greenish tint may mean that the grapefruit is high in sugar. Ugli fruit, which looks like misshapen, splotched grapefruit, is yellow with green patches and bumpy skin. Avoid: Grapefruit or ugli fruit with puff y skin or those that feel light for their size; the flesh inside is probably dry and juiceless.
Storing This Food Store grapefruit either at room temperature (for a few days) or in the refrigerator. Refrigerate grapefruit juice in a tightly closed glass bottle with very little air space at the top. As you use up the juice, transfer it to a smaller bottle, again with very little air space at the top. The aim is to prevent the juice from coming into contact with oxygen, which destroys vitamin C. (Most plastic juice bottles are oxygen-permeable.) Properly stored and protected from oxygen, fresh grapefruit juice can hold its vitamin C for several weeks.
Preparing This Food Grapefruit are most flavorful at room temperature, which liberates the aromatic molecules that give them their characteristic scent and taste. Before cutting into the grapefruit, rinse it under cool running water to flush debris off the peel. To section grapefruit, cut a slice from the top, then cut off the peel in strips—starting at the top and going down—or peel it in a spiral fashion. You can remove the bitter white membrane, but some of the vitamin C will go with it. Finally, slice the sections apart. Or you can simply cut the grapefruit in half and scoop out the sections with a curved, serrated grapefruit knife.
What Happens When You Cook This Food Broiling a half grapefruit or poaching grapefruit sections reduces the fruit’s supply of vitamin C, which is heat-sensitive.
How Other Kinds of Processing Affect This Food Commercially prepared juices. How well a commercially prepared juice retains its vitamin C depends on how it is prepared, stored, and packaged. Commercial flash-freezing preserves as much as 95 percent of the vitamin C in fresh grapefruit juices. Canned juice stored in the refrigerator may lose only 2 percent of its vitamin C in three months. Prepared, pasteurized “fresh” juices lose vitamin C because they are sold in plastic bottles or waxed-paper cartons that let oxygen in. Commercially prepared juices are pasteurized to stop the natural enzyme action that would otherwise turn sugars to alcohols. Pasteurization also protects juices from potentially harmful bacterial and mold contamination. Following several deaths attributed to unpas- teurized apple juices containing E. coli O157:H7, the FDA ruled that all fruit and vegetable juices must carry a warning label telling you whether the juice has been pasteurized. Around the year 2000, all juices must be processed to remove or inactivate harmful bacteria.
Medical Uses and/or Benefits Antiscorbutic. All citrus fruits are superb sources of vitamin C, the vitamin that prevents or cures scurvy, the vitamin C-deficiency disease. Increased absorption of supplemental or dietary iron. If you eat foods rich in vitamin C along with iron supplements or foods rich in iron, the vitamin C will enhance your body’s ability to absorb the iron. Wound healing. Your body needs vitamin C in order to convert the amino acid proline into hydroxyproline, an essential ingredient in collagen, the protein needed to form skin, ten- dons, and bones. As a result people with scurvy do not heal quickly, a condition that can be remedied with vitamin C, which cures the scurvy and speeds healing. Whether taking extra vitamin C speeds healing in healthy people remains to be proved. Possible inhibition of virus that causes chronic hepatitis C infection. In Januar y 2008, research- ers at Massachusetts General Hospital Center for Engineering in Medicine (Boston) published a report in the medical journal Hepatology detailing the effect of naringenin, a compound in grapefruit, on the behavior of hepatitis viruses in liver cells. In laborator y studies, naringenin appeared to inhibit the ability of the virus to multiply and/or pass out from the liver cells. To date, there are no studies detailing the effect of naringenin in human beings with hepatitis C.
Adverse Effects Associated with This Food Contact dermatitis. The essential oils in the peel of citrus fruits may cause skin irritation in sensitive people.
Food/Drug Interactions Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen and others. Taking aspirin or NSAIDs with acidic foods such as grapefruit may intensif y the drug’s ability to irritate your stomach and cause gastric bleeding. Antihistamines, anticoagulants, benzodiazepines (tranquilizers or sleep medications), calcium channel blockers (blood pressure medication), cyclosporine (immunosuppressant drug used in organ transplants), theophylline (asthma drug). Drinking grapefruit juice with a wide variety of drugs ranging from antihistamines to blood pressure medication appears to reduce the amount of the drug your body metabolizes and eliminates. The “grapefruit effect” was first identified among people taking the antihypertensive drugs felodipine (Plendil) and nifedip- ine (Adalat, Procardia). It is not yet known for certain exactly what the active substance in the juice is. One possibility, however, is bergamottin, a naturally occurring chemical in grapefruit juice known to inactivate cytochrome P450 3A4, a digestive enzyme needed to convert many drugs to water-soluble substances you can flush out of your body. Without an effective supply of cytochrome P450 3A4, the amount of a drug circulating in your body may rise to dangerous levels. Reported side effects include lower blood pressure, increased heart rate, headache, flushing, and lightheadedness. Some Drugs Known to Interact with Grapefruit Juice* Drug Class Generic (Brand name) Antianxiety drug Diazepam ( Valium) Antiarrhythmics Amiodarone (Cordarone) Blood-pressure drugs Felodipine (Plendil), nicardipine (Cardene), nimodipine (Nimotop), nisoldipine (Sular), verapamil ( Verelan) Cholesterol-lowering drugs Atorvastatin (Lipitor), lovastatin (Mevacor), simvastatin (Zocor), simvastatin/ezetimibe ( Vytorin) Immune Suppressants Cyclosporine (Neoral), tacrolimus (Prograf ) Impotence Drug Sildenafil ( Viagra) Pain Medication Methadone (Dolophine, Methadose) * This list may grow as new research appears.... grapefruit
Habitat: The Himalayas and southern region of western Ghats.
English: Greater Galangal.Ayurvedic: Kulanjana, Sthuula- granthi, Sugandhaa, Ugragandhaa, Malaya Vachaa, Mahaabhari- Vachaa. Substitute for Raasnaa (Pluchea lanceolata).Unani: Khulanjaan.Siddha/Tamil: Perarattai.Action: Rhizome—carminative (in dyspepsia), stomachic, circulatory stimulant, diaphoretic, anti- inflammatory.
Throughout southern India, the rhizome of Alpinia galanga is used as Raasnaa for rheumatism, intermittent fever, dyspepsia and respiratory ailments. (In the north, Vanda tessellata or Pluchea lanceolata is used as Raas- naa.)EtOH extract of the plant shows anti-inflammatory activity. The ethano- lic extract also showed significant anti- ulcer activity in rats, which has been attributed to the antisecretory and cy- toprotective properties of the plant.Major constituents of the essential oil are methyl cinnamate, cineole and d-pinene. In moderate doses, the oil exhibits antispasmodic action.Unani physicians use A. galanga as a sex tonic. In mice, the drug caused a significant gain in the weight of sexual organs and increased sperm motility and sperm count.Plants used as Raasnaa in Indian medicine: Alpinia galanga Willd. (Zingiberaceae) in southern India; Pluchea lanceolata C. B. Clarke (Compositae; Asteraceae) in Uttar Pradesh; Van- da roxburghii R. Br. (Orchidaceae) in eastern Uttar Pradesh and West Bengal; Blepharispermum subsessile DC. (Compositae; Asteraceae) in Madhya Pradesh; and Dodonaea viscosa (Linn.) Jacq. (Sapindaceae)inAndhraPradesh.Dosage: Rhizome—1-3 g powder. Decoction—50-100 ml. (CCRAS.)... alpinia galangaHabitat: Southern India, largely grown in gardens.
Ayurvedic: Panasagandhi, (Harit) Champaka.Siddha/Tamil: Manoranjidam.Folk: Haraa champaa (north), Kathari champaa; Hirvaa champaa (Maharashtra).Action: Cardiac stimulant, uterine stimulant, muscle relaxant.
The extract of the pericarp showed a positive ionotropic and chronotropic effect on all types of experimental animals. The cardiac stimulant and uterine stimulant activity is attributed to the glycosides, whereas the relaxant action on plain muscles and hypotensive effect, which could be partly choliner- gic and partly resulting from vasodila- tory action, are probably due to the presence of the volatile oil.The leaves are found to contain an antifertility principle. The root contains an antimalarial agent.... artabotrys hexapetalusHabitat: Native to Central America, often cultivated in Madhya Pradesh and South India.
English: Annatto.Ayurvedic: Sinduri, Sinduriyaa.Siddha/Tamil: Jabara, Manjitti.Action: Plant—astringent, antibil- ious, antiemetic, blood purifier. Leaves—infusion is given in jaundice, also in dysentery. Externally, scar-preventive. Root bark— febrifuge, antiperiodic. Seed pulp— haemostatic, antidysenteric, diuretic, laxative. Fruit—antidysenteric.
An antimicrobial constituent, mas- linic acid, alongwith gallic acid and pyrogallol, has been isolated from the leaves. Alcoholic extract of the leaves completely inhibited Micrococcus pyo- genes, but was inactive against E. coli. The aqueous extract, however, showed partial inhibition against E. coli. The aqueous extract also showed potent inhibitory activity towards lens aldose re- ductase, which plays an important role in the management of diabetic complications. The activity is attributed to a flavonoid, isoscutelarein.Bixin, the main constituent of seed coat, shows cytostatic effect on the growth of human lymphoma cells. Bixin also has a hyperglycaemic effect and may disturb blood glucose control.... bixa orellanaNutritional Profile Energy value (calories per serving): Low Protein: Low Fat: Low Saturated fat: Low Cholesterol: None Carbohydrates: High Fiber: High Sodium: Low (fresh or dried fruit) High (dried fruit treated with sodium sulfur compounds) Major vitamin contribution: Vitamin C Major mineral contribution: Potassium
About the Nutrients in This Food Apples are a high-fiber fruit with insoluble cellulose and lignin in the peel and soluble pectins in the flesh. Their most important vitamin is vitamin C. One fresh apple, 2.5 inches in diameter, has 2.4 g dietary fiber and 4.6 mg vitamin C (6 percent of the R DA for a woman, 5 percent of the R DA for a man). The sour taste of all immature apples (and some varieties, even when ripe) comes from malic acid. As an apple ripens, the amount of malic acid declines and the apple becomes sweeter. Apple seeds contain amygdalin, a naturally occurring cyanide/sugar compound that degrades into hydrogen cyanide. While accidentally swal- lowing an apple seed once in a while is not a serious hazard for an adult, cases of human poisoning after eating apple seeds have been reported, and swallowing only a few seeds may be lethal for a child.
The Most Nutritious Way to Serve This Food Fresh and unpared, to take advantage of the fiber in the peel and preserve the vitamin C, which is destroyed by the heat of cooking.
Diets That May Restrict or Exclude This Food Antiflatulence diet (raw apples) Low-fiber diet
Buying This Food Look for: Apples that are firm and brightly colored: shiny red Macintosh, Rome, and red Delicious; clear green Granny Smith; golden yellow Delicious. Avoid: Bruised apples. When an apple is damaged the injured cells release polyphenoloxi- dase, an enzyme that hastens the oxidation of phenols in the apple, producing brownish pigments that darken the fruit. It’s easy to check loose apples; if you buy them packed in a plastic bag, turn the bag upside down and examine the fruit.
Storing This Food Store apples in the refrigerator. Cool storage keeps them from losing the natural moisture that makes them crisp. It also keeps them from turning brown inside, near the core, a phe- nomenon that occurs when apples are stored at warm temperatures. Apples can be stored in a cool, dark cabinet with plenty of circulating air. Check the apples from time to time. They store well, but the longer the storage, the greater the natural loss of moisture and the more likely the chance that even the crispest apple will begin to taste mealy.
Preparing This Food Don’t peel or slice an apple until you are ready to use it. When you cut into the apple, you tear its cells, releasing polyphenoloxidase, an enzyme that darkens the fruit. Acid inactivates polyphenoloxidase, so you can slow the browning (but not stop it completely) by dipping raw sliced and/or peeled apples into a solution of lemon juice and water or vinegar and water or by mixing them with citrus fruits in a fruit salad. Polyphenoloxidase also works more slowly in the cold, but storing peeled apples in the refrigerator is much less effective than immersing them in an acid bath.
What Happens When You Cook This Food When you cook an unpeeled apple, insoluble cellulose and lignin will hold the peel intact through all normal cooking. The flesh of the apple, though, will fall apart as the pectin in its cell walls dissolves and the water inside its cells swells, rupturing the cell walls and turning the apples into applesauce. Commercial bakers keep the apples in their apple pies firm by treating them with calcium; home bakers have to rely on careful timing. To prevent baked apples from melting into mush, core the apple and fill the center with sugar or raisins to absorb the moisture released as the apple cooks. Cutting away a circle of peel at the top will allow the fruit to swell without splitting the skin. Red apple skins are colored with red anthocyanin pigments. When an apple is cooked, the anthocyanins combine with sugars to form irreversible brownish compounds.
How Other Kinds of Processing Affect This Food Juice. Apple juice comes in two versions: “cloudy” (unfiltered) and “clear” (filtered). Cloudy apple juice is made simply by chopping or shredding apples and then pressing out and straining the juice. Clear apple juice is cloudy juice filtered to remove solid particles and then treated with enzymes to eliminate starches and the soluble fiber pectin. Since 2000, follow- ing several deaths attributed to unpasteurized apple juice contaminated with E. coli O157: H7, the FDA has required that all juices sold in the United States be pasteurized to inactivate harmful organisms such as bacteria and mold. Note: “Hard cider” is a mildly alcoholic bever- age created when natural enzyme action converts the sugars in apple juice to alcohol; “non- alcohol cider” is another name for plain apple juice. Drying. To keep apple slices from turning brown as they dry, apples may be treated with sulfur compounds that may cause serious allergic reactions in people allergic to sulfites.
Medical Uses and/or Benefits As an antidiarrheal. The pectin in apple is a natural antidiarrheal that helps solidif y stool. Shaved raw apple is sometimes used as a folk remedy for diarrhea, and purified pectin is an ingredient in many over-the-counter antidiarrheals. Lower cholesterol levels. Soluble fiber (pectin) may interfere with the absorption of dietary fats, including cholesterol. The exact mechanism by which this occurs is still unknown, but one theory is that the pectins in the apple may form a gel in your stomach that sops up fats and cholesterol, carrying them out of your body as waste. Potential anticarcinogenic effects. A report in the April 2008 issue of the journal Nutrition from a team of researchers at the Universit y of Kaiserslautern, in Germany, suggests that several natural chemicals in apples, including but yrate (produced naturally when the pectin in apples and apple juice is metabolized) reduce the risk of cancer of the colon by nourishing and protecting the mucosa (lining) of the colon.
Adverse Effects Associated with This Food Intestinal gas. For some children, drinking excess amounts of apple juice produces intestinal discomfort (gas or diarrhea) when bacteria living naturally in the stomach ferment the sugars in the juice. To reduce this problem, the American Academy of Pediatrics recommends that children ages one to six consume no more than four to six ounces of fruit juice a day; for children ages seven to 18, the recommended serving is eight to 12 ounces a day. Cyanide poisoning. See About the nutrients in this food. Sulfite allergies (dried apples). See How other kinds of processing affect this food.
Food/Drug Interactions Digoxin (Lanoxicaps, Lanoxin). Pectins may bind to the heart medication digoxin, so eating apples at the same time you take the drug may reduce the drug’s effectiveness.... apples
Nutritional Profile Energy value (calories per serving): Low Protein: Moderate Fat: Low Saturated fat: Low Cholesterol: None Carbohydrates: High Fiber: High Sodium: Low (fresh or dried fruit) High (dried fruit treated with sodium sulfur compounds) Major vitamin contribution: Vitamin A Major mineral contribution: Iron
About the Nutrients in This Food Apricots are a good source of dietary fiber with insoluble cellulose and lignin in the skin and soluble pectins in the flesh. The apricot’s creamy golden color comes from deep yellow carotenes (including beta-carotene) that make the fruit a good source of vitamin A. Apricots also have vitamin C and iron. One apricot has 0.7 g dietary fiber, 674 IU vitamin A (21 percent of the R DA for a woman, 23 percent of the R DA for a man), and 3.5 mg vitamin C (5 percent of the R DA for a woman, 4 percent of the R DA for a man). Two dried apricot halves provide 0.6 g dietary fiber, 252 IU vitamin A (11 percent of the R DA for a woman, 8 percent of the R DA for a man), no vitamin C, and 2 mg iron (11 percent of the R DA for a woman, 25 percent of the R DA for a man). The bark, leaves, and inner stony pit of the apricot all contain amyg- dalin, a naturally occurring compound that degrades to release hydrogen cyanide (prussic acid) in your stomach. Apricot oil, treated during processing to remove the cyanide, is marked FFPA to show that it is “free from prussic acid.” Cases of fatal poisoning from apricot pits have been reported, including one in a three-year-old girl who ate 15 apricot kernels (the seed inside the pit). Extract of apricot pits, known medically as Laetrile, has been used by some alternative practitioners to treat cancer on the theory that the cyanide in amygdalin is released only when it comes in contact with beta-glucuronidase, an enzyme common to tumor cells. Scientifically designed tests of amygdalin have not shown this to be true. Laetrile is illegal in the United States.
The Most Nutritious Way to Serve This Food Ounce for ounce, dried apricots are richer in nutrients and fiber than fresh ones.
Diets That May Restrict or Exclude This Food Low-fiber diet Low-potassium diet Low-sodium diet (dried apricots containing sodium sulfide)
Buying This Food Look for: Firm, plump orange fruit that gives slightly when you press with your thumb. Avoid: Bruised apricots. Like apples and potatoes, apricots contain polyphenoloxidase, an enzyme that combines with phenols in the apricots to produce brownish pigments that discolor the fruit. When apricots are bruised, cells are broken, releasing the enzyme so that brown spots form under the bruise. Avoid apricots that are hard or mushy or withered; all are less flavorsome than ripe, firm apricots, and the withered ones will decay quickly. Avoid greenish apricots; they are low in carotenes and will never ripen satisfactorily at home.
Storing This Food Store ripe apricots in the refrigerator and use them within a few days. Apricots do not lose their vitamin A in storage, but they are very perishable and rot fairly quickly.
Preparing This Food When you peel or slice an apricot, you tear its cells walls, releasing polyphenoloxidase, an enzyme that reacts with phenols in the apricots, producing brown compounds that darken the fruit. Acids inactivate polyphenoloxidase, so you can slow down this reaction (but not stop it completely) by dipping raw sliced and/or peeled apricots into a solution of lemon juice or vinegar and water or by mixing them with citrus fruits in a fruit salad. Polyphenoloxidase also works more slowly in the cold, but storing peeled apricots in the refrigerator is much less effective than an acid bath. To peel apricots easily, drop them into boiling water for a minute or two, then lift them out with a slotted spoon and plunge them into cold water. As with tomatoes, this works because the change in temperature damages a layer of cells under the skin so the skin slips off easily.
What Happens When You Cook This Food Cooking dissolves pectin, the primary fiber in apricots, and softens the fruit. But it does not change the color or lower the vitamin A content because carotenes are impervious to the heat of normal cooking.
How Other Kinds of Processing Affect This Food Juice. Since 2000, following several deaths attributed to unpasteurized apple juice contami- nated with E. coli O157:H7, the FDA has required that all juices sold in the United States be pasteurized to inactivate harmful organisms such as bacteria and mold. Drying. Five pounds of fresh apricots produce only a pound of dried ones. Drying removes water, not nutrients; ounce for ounce, dried apricots have 12 times the iron, seven times the fiber, and five times the vitamin A of the fresh fruit. Three and a half ounces of dried apricots provide 12,700 IU vitamin A, two and a half times the full daily requirement for a healthy adult man, and 6.3 mg of iron, one-third the daily requirement for an adult woman. In some studies with laboratory animals, dried apricots have been as effective as liver, kidneys, and eggs in treating iron-deficiency anemia. To keep them from turning brown as they dry, apricots may be treated with sulfur dioxide. This chemical may cause serious allergic reactions, including anaphylactic shock, in people who are sensitive to sulfites.
Medical Uses and/or Benefits * * *
Adverse Effects Associated with This Food Sulfite allergies. See How other kinds of processing affect this food.
Food/Drug Interactions * * *... apricots
Symptoms formerly grouped under this term are now included in the more specific diagnostic categories of conversion disorder; somatization disorder; dissociative disorders; and factitious disorders.
The term is still used loosely to describe irrational behaviour.... hysteria
Pterygium is attributed to prolonged exposure to bright sunlight and is common in tropical areas.
It is surgically removed if it threatens vision or causes discomfort.... pterygium
Habitat: Throughout India as a weed.
English: Horse-purslane, Hogweed.Ayurvedic: Rakta-punarnavaa, Punarnavaa, Katthilla, Shophaghni, Shothaghni. Varshaabhu (also equated with Trianthema portu- lacastrum Linn., which exhibits anti-inflammatory, antipyretic and analgesic activity).Unani: Itsit, Bishkhaparaa.Siddha/Tamil: Mookkirattai.Folk: Gadaha-purnaa.Action: Diuretic, anti-inflammatory, antiarthritic, spasmolytic, antibacterial (used for inflammatory renal diseases, nephrotic syndrome, in cases of ascites resulting from early cirrhosis of liver and chronic peritonitis, dropsy associated with chronic Bright's diseases, for serum uric acid levels). Root—anticon- vulsant, analgesic, expectorant, CNS depressant, laxative, diuretic, abortifacient.
Key application: As diuretic, hepatoprotective. (Indian Herbal Pharmacopoeia.)B. repanda, synonym B. chinensis Linn., roots exhibited antihepatotox- ic activity against carbon tetrachloride galactosamine-and paracetamol- induced intoxication in rats. Powdered root gave encouraging results in spermatorrhoea and leucorrhoea.The chloroform and methanolic extracts of the roots and aerial parts of B. diffusa also exhibited antihepatotox- ic activity against carbon tetrachloride- induced intoxication in rats.Punarnavaa is official in IP as a diuretic. The diuretic action of the drug is attributed to the presence of xanthone, beta-ecdysone. Flavonoid, arbinofura- noside, present in the drug, was found to lower serum uric acid in experimental animals, as also in humans.Punarnavaa has been reported to increase serum protein level and reduce urinary protein extraction in clinical trials in patients suffering with nephrotic syndrome. The activity is attributed to the presence of rotenoids in various parts of the plant.An antifibrinolytic agent, punar- navoside, has been found to stop IUCD-induced bleeding in monkeys. The drug contains quinolizidine alkaloids.Dosage: Whole plant—20-30 g for decoction (API Vol. I); root—1-3 g powder; 10-20 ml fresh juice. (API Vol. III.)... boerhavia diffusaHabitat: The Himalayas from Kashmir to Bhutan and the Khasi Hills, at 1,000-4,000 m.
English: Hare's Ear.Folk: Shingu (Himachal Pradesh), Sipil (Punjab), Thaanyo (Garhwal).Action: Roots—anti-inflammatory, haemolytic, antipyretic. Used in inflammations, muscle stiffness, neurosis, pain and pyrexia. Roots resolve inflammations of costal margin and diaphragm.
Key application: Extracts have been used for the treatment of chronic hepatitis, nephrotic syndrome and auto-immune diseases (WHO.).Therapeutic properties are attributed to saikoside or saikosaponins (yield from roots 2.06-3.02%), a complex mixture of triterpenic saponins. Saponin content varies with age. Saikos- aponins are analgesic, antipyretic as well as antitussive; anti-inflammatory on oral administration. In Japan and China, roots have been used traditionally in auto-immune diseases. Saikos- aponins form an ingredient of anti- tumour pharmaceuticals. A water- soluble crude polysaccharide fraction, prepared from the root, was reported to prevent HCl/ethanol-induced ulcero- genesis in mice significantly. Saiko- saponin-d, at a concentration of more than 5 ^m, inactivated measles virus and herpes simplex virus at room temperature.Several sterols, possessing metabolic activities and plasma cholesterol- lowering activity, have also been isolated from the root.... bupleurum flacutumHabitat: Native to India and Malaysia. Cultivated in Bengal and South India, also grown as a hedge plant.
English: Sappan.Ayurvedic: Pattanga, Patanga, Pattraanga, Raktasaara, Ranjana, Pataranjaka, Suranga, Kuchandana.Unani: Bakam.Siddha/Tamil: Patangam, Anaikun- trumani.Folk: Patang.Action: Wood decoction— emmenagogue, antidiarrhoeal; used in skin diseases.
The heartwood gave an anti-inflammatory principle brazilin; amyrin glu- coside, amino acids and carbohydrates. EtOH (50%) extract of stem exhibited semen coagulant activity Aqueous and chloroform extracts of the wood exhibited inhibitory action on cyclic AMP phosphodiesterase. The methanolic extract of the sappan lignan showed sleep-time-elongation effect in mice. Significant anti-hypercholes- terolaemic activity is attributed to ben- zilic compounds.The oil exhibited antibacterial and antifungal activity.Plant pigments find use in facials which are resistant to light, heat and water and are non-irritating.Dosage: Heartwood—5-10 g (API Vol. IV.)... caesalpinia sappanHabitat: Cultivated as pulse crop, chiefly in Madhya Pradesh, Bihar, Andhra Pradesh, Maharashtra, Uttar Pradesh and Karnataka.
English: Pigeon Pea, Red Gram.Ayurvedic: Aadhaki, Tuvari, Tuvara, Shanapushpikaa.Unani: Arhar.Siddha/Tamil: Thuvarai.Action: Green leaves are considered hypocholesterolaemic. Pulse shows cholesterol and phospholipid lowering effect (reported to cause flatulence). A paste of leaves with salt and water, is taken on an empty stomach for jaundice. Leaves are used in diseases of the mouth, and topically for treating measles and other eruptions.
The Ayurvedic Pharmacopoeia ofIn- dia indicated the use of the seed in lipid disorders and obesity; externally for promoting breast development, and attributed blood purifying properties to the root.Amino acid analysis of the seed extract showed that phenylalanine (26.3% of the total amino acids) is responsible for about 70% of the anti- sickling potency of the seed extract.Seeds also contain riboflavin and pyridoxine. Root bark contains isofla- vones, sterols, triterpenoids, flavones, anthraquinone derivatives. Plant also contains an isoflavone, cajanol.The aqueous extract of leaves showed vasodilatory effect in experimental animals.Unroasted nuts had hypoglycaemic effect in mice; roasted seeds, in contrast, had a hyperglycaemic effect. (Sharon M. Herr.)Dosage: Root—2-6 g powder. (API Vol. III.)... cajanus cajanHabitat: Throughout India; wild in Punjab.
English: Pot-Marigold, Marigold; Calendula.Unani: Zergul.Siddha/Tamil: Thulvkka Saamanthi.Action: Flowers—antiinflammatory, antiseptic, stimulant, antispasmodic, emmenagogue, antihaemorrhagic, styptic. Used in gastric and duodenal ulcers and dysmenorrhoea; externally for cuts, bruises, burns, scalds. Plant—antiprotozoal. Flower— antimicrobial. Essential oil— antibacterial.
Key application: In inflammation of the oral and pharyngeal mucosa, internally and externally. Externally, on poorly healing wounds, ul- cuscruris. (German Commission E, WHO, ESCOP.) Anti-inflammatory, vulnerary. (The British Herbal Pharmacopoeia.)The flowers contain triterpenes, sterols, flavonoids, carotenes, bitter glycosides, resins, volatile oil, mucilage (do not contain tannins). Polysaccharides from flowers exhibited immuno- stimulating and antitumour activity in several in vitro test systems.An alcoholic extract has been shown to have antitrichomonal activity.Wound healing and antiinflammatory properties are attributed to Mn and carotene. An aqueous alcoholic extract of florets showed CNS inhibitory effect with marked sedative activity in experimental animals.The extract of flower-heads exhibited estrogenic activity (reduces period pains and regulates menstrual bleeding).Calephlone, the extract containing the total polyphenols of the inflorescence, has a marked cholagogic effect in rats and has been found helpful in the treatment of CCl4-induced hepatitis. A hypocholesterolaemic saponin has been extracted from the plant.Dosage: Dried inflorescences powder—1-3 g (API Vol. II); fruit powder—1-2 g. (API Vol. IV.)... calendula officinalisHabitat: Rajasthan, Punjab and Sindh; southward to Karnataka and Tamil Nadu.
English: Caper Berry.Ayurvedic: Karira, Krakar, Apatra, Granthila, Marubhoo-ruuha, Niguudhapatra, Karila.Unani: Kabar, Kabar-ul-Hind, Kabar-e-Hindi; Tenti.Siddha/Tamil: Chhengan.Folk: Tenti.Action: Anti-inflammatory (used for enlarged cervical glands, sciatica, rheumatoid arthritis; externally on swellings, skin eruptions, ringworm). Fruits and seeds—used for urinary purulent discharges and dysentery. Flowers and seeds— antimicrobial. The fruit is used as a pickle.
The root bark contains spermidine alkaloids, used for inflammations, asthma and gout.Activity of the seed volatiles against vibro cholerae has been recorded.Aqueous extract of the plant exhibits anthelmintic activity; seeds contain antibacterial principles—glucocapparin; isothiocynate aglycone of glucocap- parin.The blanched fruits, when fed to rats at 10% dietary fibre level, showed a significant hypocholesterolaemic effect, which is attributed to its hemicel- lose content.Pickled fruits are use for destroying intestinal worms.Dosage: Leaf, root—50-125 mg (CCRAS.)Folk: Hains, Kanthaar.Action: Antiseptic, antipyretic. Used for eczema and scabies.
Leaves contain taraxasterol, alpha- and beta-amyrin and beta-sitosterol, erythrodiol and betulin.Dosage: Root—5-10 g powder. (CCRAS.)... capparis aphyllaHabitat: Native to Sudan and Arabia. Now cultivated mainly in Tirunelveli and Ramnathpuram districts and to a lesser extent in Madurai, Salem and Tiruchirapalli districts of Tamil Nadu. Also grown on a small scale in Cuddapah district of Andhra Pradesh and certain parts of Karnataka.
English: Indian Senna, Tinnevelly Senna.Ayurvedic: Svarna-pattri, Maarkandikaa, Maarkandi.Unani: Sannaa, Sanaa-makki, Senaai, Sonaamukhi, Sanaa-Hindi.Siddha/Tamil: Nilaavaarai.Folk: Sanaai.Action: Purgative (free from astringent action of rhubark type herbs, but causes gripe), used in compounds for treating biliousness, distention of stomach, vomiting and hiccups. Also used as a febrifuge, in splenic enlargements, jaundice, amoebic dysentery. Contraindicated in inflammatory colon diseases.
Key application: Leaf and dried fruit—in occasional constipation. (German Commission E.) As a stimulant laxative. (The British Herbal Pharmacopoeia.) 1,8- dihydoxy-anthracene derivatives have a laxative effect. This effect is due to the sennosides, specifically, due to their active metabolite in the colon, rheinanthrone. The effect is primarily caused by the influence on the motility of the colon by inhibiting stationary and stimulating propulsive contractions. (German Commission E, ESCOP, WHO.) Seena has been included in I.P. as a purgative.Most of the Senna sp. contain rhein, aloe-emodin, kaempferol, isormam- netin, both free and as glucosides, together with mycricyl alcohol. The purgative principles are largely attributed to anthraquinone derivatives and their glucosides.Senna is an Arabian name. The drug was brought into use by Arabian physicians for removing capillary congestion (pods were preferred to leaves).The active purgative principle of senna was discovered in 1866.Cassia acutifolia Delile is also equated with Maarkandikaa, Svarna-pattri, Sanaai.Dosage: Leaves—500 mg to 2 g (API Vol. I.)... cassia angustifoliaHabitat: Native to Europe; commonly occurs in North West India, Tamil Nadu and parts of Andhra Pradesh.
English: Chicory, Indian Endive.Ayurvedic: Kaasani.Unani: Kaasani Dashti (Barri).Siddha/Tamil: Kasinikkeerai.Action: Diuretic, laxative, chol- agogue, mild hepatic. Excites peristalsis without affecting the functions of the stomach. Used in liver congestion, jaundice, rheumatic and gouty joints.
Key application (herb and root): In loss of appetite, dyspepsia. (German Commission E.)The herb contains inulin (up to 58% in the root); sesquiterpene lactones (including lactucin and lactucopicrin); coumarins (chicoriin, esculetin, es- culin, umbelliferone and scopoletin); the root includes a series of glucofruc- tosans. Raw chicory root contains only citric and tartaric acids; roasted chicory contains acetic, lactic, pyru- vic, pyromucic, palmitic and tartaric acids. The carcinogenic hydrocarbons and floranthene are also reported in the chicory (a potent carcinogen 3,4- benzpyrene has been detected).Added to coffee, chicory root counteracts caffeine and helps in digestion.An alcoholic extract of the plant was found effective against chlorproma- zine-induced hepatic damage in adult albino rats. The cholagogue activity is attributed to polyphenols.The sedative effect of chicory is attributed to lactucopicrin. The sedative effect antagonizes the stimulant effect of tea and coffee. (Natural Medicines Comprehensive Database, 2007.)The extracts of roots were found to be active against several bacteria.Dosage: Seed—3-6 g powder; leaf—10-20 ml juice; root—50- 100 ml. (CCRAS.)... cichorium intybusHabitat: Cultivated in West Bengal and Tamil Nadu.
English: Crown or Loxa Bark.Ayurvedic: Quinine.Unani: Al-keenaa, Kanakanaa.Action: Antimalarial, febrifuge, astringent, orexigenic, sapasmolytic. Also prescribed in amoebic dysentery, jaundice, atonic dyspepsia, night cramps. Sometimes causes gastric and intestinal irritation.
Key application: In peptic discomforts such as bloating and fullness, loss of appetite. (German Commission E.)The bark contains alkaloids quinine (2.35-4.42%); quinidine (1.44-2.56%); cinchonine (0.10-0.66%); cinchoni- dine (0.49-0.89%) and other alkaloids, quinamine, javanine (0.14-0.63%).The leaves contain quercetin, kaem- pferol and avicularin.Quinine is antimalarial; quinidine is antiarrhythmic and cardiac tonic, also used in psychic treatments.The bark shows potent inhibitory activity against polymorphonuclear leucocytes; the activity is attributed to the alkaloids of the bark. Cinchona may potentiate coumarin derivatives. In large doses, it is sedative to CNS and cardiac plexus.Quinine is toxic at over 3 g, quini- dine at 1 g.Related Cinchona sp.: C. calisaya Wedd. (Nilgiris and Sikkim); C. calisaya Wedd. var. ledgeriana How. (West Bengal, Khasi Hills and Tamil Nadu); and C. succirubra Pav. ex Klotz. (Nilgiris and Annamalis in Tamil Nadu, Sikkim and West Bengal).The bark of all the species contain quinine, quinidine, cinchonine and cinchonidine and exhibit antimalarial activity. The alcoholic extract of C. ledgeriana Moens ex Trimen bark exhibits antibacterial activity against Gram-positive bacteria comparable to sodium penicillin. The extract, however, exhibits lesser activity than di- hydrostreptomycin sulphate against Gram-negative bacteria.... cinchona officinalisHabitat: The tropical and subtropical parts of India.
English: Velvet-Leaf Pareira, Pareira Brava.Ayurvedic: Paathaa, Ambashthaa, Varatiktaaa, Vriki, Aviddhakarni, Piluphalaa, Shreyashi.Bigger var., Raaja Paathaa, is equated with Stephania hernandifolia Walp.)Unani: Paathaa.Siddha/Tamil: Paadakkizhangu, Appatta.Action: Root astringent, an- tispasmodic (used for cramps, painful menstruation), analgesic, antipyretic, diuretic, antilithic and emmenagogue. Prescribed for diarrhoea, dysentery, piles, urogenital affections (cystitis, nephritis, menorrhagia) Root paste is applied topically on scabies and eruptions on the body. Also used for preventing miscarriage.
The Ayurvedic Pharmacopoeia ofIn- dia attributed blood purifying properties to the root and indicated it in lactal disorders.Hayatine (dl-beberine) is the principal alkaloid of the root. Its derivatives, methiodide and methochloride are reported to be potent neuromus- cular-blocking agents.Not to be confused with Abuta grandiflora, a South American medicinal plant.Dosage: Root—3-6 g powder. (API Vol. I.) the plant hastens fracture-healing by reducing the total convalescent period by 33% in experimental rats and dogs; it aids in recovery of the strength of the bones up to 90% in 6 weeks.Dosage: Stem—10-20 ml juice. (API Vol. III.)... cissampelos pareiraHin: Patharchur;
Ben: Paterchur;Mal: Panikkurkka, kannikkurkka;Tam: Karpuravalli;Kan: karpurahalli;Tel: Sugandhavalkam.It is found through out the tropics and cultivated in homestead gardens. It is a large succulent aromatic perennial herb with hispidly villous or tomentose fleshy stem. Leaves are simple, opposite, broadly ovate, crenate and fleshy. Flowers are pale purplish in dense whorls at distant intervals in a long slender raceme. Fruits are orbicular or ovoid nutlets. The leaves are useful in cephalagia, otalgia, anorexia, dyspepsia, flatulence, colic, diarrhoea, cholera, halitosis, convulsions, epilepsy, cough, asthma, hiccough, bronchitis, strangury, hepatopathy and malarial fever (Warrier et al,1995).2. Coleus vettiveroides K.C. Jacob, syn. Plectranthus vettiveroides (Jacob) Singh & Sharma.San: Valakam, Hriberam;Hin: Valak;Mal: Iruveli;Tam: Karuver;Tel: Karuveru,It is seen in tropical countries and cultivated in gardens. It is a small profusely branched, succulent aromatic herb with quadrangular stems and branches and deep straw coloured aromatic roots. Leaves are glandular hairy, broadly ovate with dentate margins and prominent veins on the bark. Blue flowers are borne on terminal racemes. Fruits are nutlets. The whole plant is useful in hyperdipsia, vitiated conditions of pitta, burning sensation, strangury, leprosy, skin diseases, leucoderma, fever, vomiting, diarrhoea, ulcers and as hair tonic.3. Coleus forskohlii Briq. syn. C. barbatus Benth.Hin: Garmai
Kan: Maganiberu, MakandiberuGuj: MaimulIt is a perennial aromatic herb grown under tropical to temperate conditions for its carrot-like tubers which are used as condiments in the preparation of pickles. Its tuberous roots are an exclusive source of a diterpenoid forskolin which has the unique property of activating almost all hormone sensitive adenylate cyclase enzymes in a biological system. It is useful in the treatment of congestive heart failure, glaucoma, asthma, cancer and in preventing immature greying of hair (Hegde,1997).Agrotechnology: The Coleus group of plants grows in tropical to subtropical situations and in warm temperate climatic zone on mountains of India, Nepal, Burma, Sri Lanka, Thailand and Africa. It comes up well on the sun exposed dry hill slopes from 300m to 1800m altitude. A well drained medium fertile soil is suitable for its cultivation. it is propagated vegetatively through stem and root cuttings. Vine cuttings to a length of 10-15cm from the top portion are most ideal for planting. The land is ploughed or dug to a depth of 15-20cm and ridges are formed 30cm apart. Vine cuttings are planted on the ridges at 30cm spacing after incorporating basal manure. 10t of FYM and NPK at 50:50:50kg/ha are incorporated into the soil. Top dressing of N and K is also suggested for improved yields. Weeding and earthing up at 45 days after planting along with topdressing is highly beneficial. Bacterial wilt and root knot nematode are reported in the crop. Drenching the soil with fungicide, deep ploughing in the summer, burning of crop residues and crop rotation are helpful to tide over the disease and pest problem. The crop can be harvested after 5-6 months.Properties and activity: The medicinal property of Coleus amboinicus is attributed to codeine, carvacrol, flavones, aromatic acids and tannins present in the plant. The essential oil from the plant contains carvacrol, ethyl salicylate, thymol, eugenol and chavicol. Leaves also contain cirsimaritin, -sitosterol- -D-glucoside and oxalacetic acid. Leaves are bitter, acrid, thermogenic, aromatic, anodyne, appetising, digestive, carminative, stomachic, anthelmintic, constipating, deodorant, expectorant, diuretic and liver tonic.Coleus vettiveroides is bitter, cooling, diuretic, trichogenous and antipyretic.Coleus forskohlii roots are rich in diterpenoids like forskolin, coleonols, coleons, barbatusin, cyclobutatusin, coleosol, coleol, coleonone, deoxycoleonol, 7-deacetylforskolin and 6-acetyl-7-deacetylforskolin. Its root is spasmolytic, CNS active, hypothermic and diuretic. Forskolin is bronchodialative and hypotensive (Hussain et al,1992). Forskolin is also useful in preventing the clotting of blood platelets, in reducing intraocular pressure in glaucoma and as an aid to nerve regeneration following trauma (Sharma, 1998)... coleusHabitat: Wild as well as cultivated in gardens all over India.
Ayurvedic: Varuna, Varana, Barnaa, Setu, Ashmarighna, Kumaarak, Tiktashaaka.Unani: Baranaa.Siddha/Tamil: Maavilingam.Action: Bark—diuretic (finds application in urinary disorders, including urolithiasis, prostatic hypertrophy, neurogenic bladder and urinary infections; uterine and gastro-intestinal problems). Juice of the bark is given to women after childbirth. Extract of root bark, mixed with honey, is applied to scrofulous enlargements of glands. Whole plant powder—cholinergic in smooth muscles including urinary bladder.
Key application: As antiurolithiatic. (Indian Herbal Pharmacopoeia.)The antiurolithic activity of the stem-bark is attributed to the presence of lupeol. Lupeol not only prevented the formation of vesical calculi, but also reduced the size of the preformed stones in the kidneys of calculogenic rats. It also reversed the biochemical parameters in urine, blood and serum towards normal.The stem bark also exhibit anti- inflammatory activity, and is reported to stimulate bile secretion, appetite and bowel movement.Dosage: Stem bark—20-30 g for decoction. (API Vol. I.)... crataeva nurvalaHabitat: Wild as well as cultivated as an ornamental.
English: Wide-leaved Crinum.Ayurvedic: Sudarshana, Sukhadar- shana, Chakraangi, Somvalli, Madhuparnikaa.Siddha/Tamil: Vishamoongil.Action: Bulb—rubefacient, an- tirheumatic. Also used for piles and tubercular fistula.
The alkaloids, crinafoline and crina- folidine, have been isolated from the plant. These along with crinafoline methochloride exhibited significant tumour-inhibiting activity in vivo. The plant extract in also used in allergic condition. This activity is attributed to the presence of glucan A and phos- phatidyllycorine.A related species, C. zeylanicum, is known as Milk-and-Wine Lily.Dosage: Leaf, root—5-10 g paste. (CCRAS.)... crinum latifoliumHabitat: Himalayas from Kashmir to Assam, ascending up to more than 300 m and in the north-western plains.
Ayurvedic: Bhuutikaa, Laamajja- ka, Laamajja. (Subs. Vetiveria zizanioides (L.) Nash.)Unani: Izkhar.Action: Blood purifier, bechic, anticholerin, emmenagogue, febrifuge, antirheumatic (also used in gout). Flower—styptic. Essential oil—antimicrobial.
Major constituent of the essential oil is piperitone (64.7%) others include borneol, cadinene, camphene, camphor, farnesene, geraniol, alpha-and beta-pinene. The antibacterial activity is attributed to piperitone.... cymbopogon jwarancusaHabitat: Throughout India, as a weed upto 2,000 m.
English: Nut Grass.Ayurvedic: Musta, Mustaa, Mus- taka, Abda, Ambuda, Ambhoda, Ambodhara, Bhadra, Bhadraa, Bhadramusta, Bhadramustaa, Bhadramustaka, Ghana, Jalada, Jaldhara, Meghaahvaa, Nirada, Vaarida, Vaarivaaha, Payoda, Balaahaka. Ganda-Duurvaa (var.).Unani: Naagarmothaa, Saad-e-Kufi.Siddha/Tamil: Koraikkizhangu.Folk: Mothaa.Action: Carminative, astringent, anti-inflammatory, antirheumat- ic, hepatoprotective, diuretic, antipyretic, analgesic, hypoten- sive, emmenagogue and nervine tonic.
Used for intestinal problems, indigestion, sprue, diarrhoea, dysentery, vomiting and fever; also as a hypoc- holesterolaemic drug and in obesity.Along with other therapeutic applications, The Ayurvedic Pharmacopoeia of India indicated the use of the rhizome in rheumatism, inflammations, dysuria, puerperal diseases and obesity.The tuber is rich in Cu, Fe, Mg and Ni. Beta-sitosterol, isolated from the tubers, exhibits significant anti- inflammatory activity against carra- geenan- and cotton pellet-induced oedema in rats; the activity is comparable to hydrocortisone and phenylbutazone when administered intraperi- toneally.The alcoholic and aqueous extracts of the tubers possess lipolytic action and reduce obesity by releasing enhanced concentrations of biogenic amines from nerve terminals of the brain which suppress the appetite centre. Presence of eudalne group of ses- quiterpenic compounds of sesquiter- pene alcohol, isocyperol is said to play an important role in lipid metabolism.An alcoholic extract of the plant exhibits liver-protective activity against CCL4-induced liver damage in mice.Methanolic extract of the plant stimulates the production of melanin in cultured melanocytes. (Plant extract is used in preparations used for pigmentation of skin and hair, also in suntan gels.) Aqueous-alcoholic extract of the tuber exhibited hypotensive, diuretic, antipyretic and analgesic activities. These are attributed to a triterpenoid.The essential oil (0.5-0.9%) from the tubers contains mainly sesquiterpenes.C. platystilis Br. is equated with Kaivarta-mustaka.Dosage: Rhizome—3-6 g powder; 20-30 ml decoction. (API Vol. III.)... cyperus rotundusHabitat: Persia and Afghanistan.
English: Zalil Larkspur.Ayurvedic: Sprikkaa. (Melilotus officinalis, known as Aspurka or Naakhunaa, is also equated with Sprikkaa.)Unani: Zarir, Zalil, Asbarg, Gul-Zalil (flower).Action: Diuretic, anodyne, anti- inflammatory, detergent. Used in jaundice, dropsy and diseases of the spleen. Ash—used externally on wounds and skin diseases.
The seeds contain norditerpenoid alkaloid, zaliline, besides anhweidel- phinine, browniine, desacetylnudi- cauline, lycoctonine, methyllycaconi- tine and nudicauline. The medicinal properties of the plant are attributed to desacetylnudicauline, methyllycaconi- tine and nudicauline.... delphinium zalilHabitat: Throughout India, up to 2,438 m.
Ayurvedic: Brahma-suvarchalaa (doubtful synonym).Folk: Mukhjali. (Drosera burmannii Vahl is also known as Mukhjali.)Action: Resin from plant—used in bronchitis and whooping cough. Plant—antisyphyilitic. Bruised leaves, mixed with salt are applied for treating blisters.
Key application: Drosera rotundifo- lia—in dry cough and coughing fits, as bronchoantispasmodic. (German Commission E.).The leaves contain napthaquinones, plumbagin (0.5%), droserone (3-hy- droxyplumbagin) and hydroxydro- serone (0.01%), and the flavonoids, quercetin, gossypetin, gossypin and isogossypitrin. The antispasmodic action of the herb has been attributed to naphthoquinones. Plumbagin is antimicrobial in vitro against some Gram-positive and Gram-negativebac- teria, influenza virus, pathogenic fungi and parasitic protozoa, and is active against some species of Leishmania. In large doses plumbagin is cytotoxic, but in small doses exhibits immunostimu- lating activity in vitro.A related species, Drosera indica Linn., is found in Deccan peninsula, particularly in the West coast. Plum- bagone, isolated from the plant, depresses the isolated intestine of the guinea-pig and suppresses the effect of acetylcholine. In Indo-China, a maceration of the plant is applied topically to corns.In Western herbal, Sundew is obtained from the aerial parts of Drosera rotundifolia which grows throughout Europe.... drosera peltataThe term is also a street drug name for an amphetamine derivative, 3, 4-methylenedioxymethamphetamine or MDMA, increasingly used as a ‘recreational’ drug. It is classi?ed as a class A drug under the Misuse of Drugs Act 1971. MDMA is structurally similar to endogenous CATECHOLAMINES and produces central and peripheral sympathetic stimulation of alpha and beta ADRENERGIC RECEPTORS. It is taken into nerve terminals by the serotonin transporter and causes release of the NEUROTRANSMITTER substances serotonin and dopamine. Following this, SEROTONIN depletion is prolonged. As serotonin plays a major part in mood control, this leads to the characteristic ‘midweek depression’ experienced by MDMA users.
Several fatalities in young people have been attributed to adverse reactions resulting from MDMA use/abuse and possibly accompanying alcohol consumption. The principal effects are increase in pulse, blood pressure, temperature and respiratory rate. Additional complications such as cardiac ARRHYTHMIA, heatstroke-type syndrome, HYPONATRAEMIA and brain haemorrhage may occur. There is also concern over possible effects on the mental concentration and memory of those using ecstasy.
Management of patients who get to hospital is largely symptomatic and supportive but may include gastric decontamination, and use of DIAZEPAM as the ?rst line of treatment as it reduces central stimulation which may also reduce TACHYCARDIA, HYPERTENSION and PYREXIA.... ecstasy
Habitat: The Himalayas at high altitudes.
English: Field Horsetail.Ayurvedic: Ashwa-puchha (non- classical).Action: Haemostatic, haemopoietic, astringent, diuretic. Used for genitourinary affections (urethritis, enuresis, cystitis, prostatitis), internally as an antihaemorrhagic and externally as a styptic.
The ashes of the plant are beneficial in acidity of the stomach and dyspepsia.Key application: Internally in irrigation therapy for post-traumatic and static inflammation, and for bacterial infections and inflammation of the lower urinary tract and renal gravel.The British Herbal Compendium reported weak diuretic, haemostyptic, vulnerary and mild leukocytosis causing actions.The haemostatic substance has been shown to act orally, it has no effect on blood pressure and is not a vasoconstrictor.The herb contains 10-20% minerals, of which over 66% are silicic acids and silicates; alkaloids, including nicotine, palustrine and palustrinine; flavonoids, such as iso-quercitrin and equicertin; sterols, including cholesterol, isofucosterol, campesterol; a sa- ponin equisitonin, dimethyl-sulphone, thiaminase and aconitic acid. Diuretic action of the herb is attributed to its flavonoid and saponin constituents, Silicic acid strengthens connective tissue and helps in healing bones.... equisetum arvenseHabitat: The temperate Himalayas up to 3,600 m and in Khasi Hills between 1,000 and 2,000 m.
English: Hemp Agrimony, Water Hemp, Hemp Eupatorium.Folk: Bundaar (Maharashtra), Tongollati (Assam).Action: Diuretic, cathartic, anti-tumoral. Used under strict medical supervision for blood impurities and tumours. Internal administration is not advised unless the hepatotoxic alkaloids are shown to be absent from the sample.
The herb contains volatile oil (about 0.5%); sesqiterpene lactones, the major one being eupatoriopicrin; flavonoids, pyrrolizidine alkaloids; immunoactive polysaccharides.Eupatoriopicrin has shown to be cy- tostatic as well as cytotoxic; it delayed transplanted tumour growth in mice in a dose-dependent manner.An aqueous extract of the plant exhibited anti-necrotic activity against carbon tetrachloride-induced hepato- toxicity in rats. The effect is attributed to the presence of flavonoids, rutoside, hyperoside and quercetin; phenolic acids, caffeic and chlorogenic; and not due to the presence of eupatoriopicrin.Acrylic acid and the lactic, malic and citric acids, present in the plant, also exhibited protective effect against acute toxicity induced by ethanol in mice.The polysaccharides have immuno- stimulatory activity and enhance phagocytosis in a number of immunolog- ical tests. The leaf oil is reported to exhibit fungicidal effect.A related species, Eupatorium odorum Linn., is known as Gondri in Ori- ssa.... eupatorium cannabinumHabitat: Throughout warmer regions of India.
English: Euphorbia, Australian Asthma Weed, Pill-bearing Spurge.Ayurvedic: Dudhi, Dudhikaa, Naagaarjuni, Vikshirini.Unani: Dudhi Khurd.Siddha/Tamil: Amman pachharisi.Action: Pectoral, antiasthmatic, antispasmodic. Used for asthma, laryngitis, chronic nasal and bronchial catarrh; diarrhoea, dysentery, intestinal parasitosis Also used in postnatal complaints, failure of lactation. Latex— vermifuge. Used in diseases of urinogenitory tract.
The herb contains several terpenes, anthocyanins, alcohols and steroids. Aerial parts also gave shikimic acid, choline, L-inositol and free sugars.Antiasthmatic activity is attributed to choline and shikimic acid. Shikimic acid and choline showed relaxant and contracting properties on guinea-pig ileum.The aqueous extract of the herb exhibited sedative, anxiolytic, analgesic, antipyretic and anti-inflammatory activities; exerted an inhibitory effect on platelet aggregation.Quercitrin is reported to be responsible for antidiarrhoeal activity.Methanolic extract of the leaves exhibits antibacterial and antifungal activities.Dimeric hydrolysable tannins, eu- phorbains, have been isolated from the plant.... euphorbia hirtaHabitat: Sub-Himalayan tract and Peninsular India. Planted along roadsides, and in gardens.
English: Banyan tree.Ayurvedic: Vata, Nyagrodha, Bahupaada, Dhruv.Unani: Bargad, Darakht-e-Reesh.Siddha/Tamil: Aalamaram.Action: Infusion of bark—used in diabetes, dysentery, and in seminal weakness, leucorrhoea, menorrhagia, nervous disorders, erysipelas, burning sensation. Milky juice and seeds—applied topically to sores, ulcers, cracked soles of the feet, rheumatic inflammations. Buds—a decoction in milk is given in haemorrhages. Aerial roots— antiemetic, topically applied to pimples. Leaves—a paste is applied externally to abscesses and wounds for promoting suppuration.
Along with other therapeutic applications, The Ayurvedic Pharmacopoeia of India recommends the aerial root in lipid disorders.Phytosterolin, isolated from the roots, given orally to fasting rabbits at a dose of 25 mg/kg, produced maximum fall in blood sugar level equivalent to 81% of the tolbutamide standard after 4 h. The root bark showed antidiabetic activity in pituitary diabetes and alloxan-induced diabetes.The alcoholic extract of the stem bark also exhibited antidiabetic activity on alloxan-induced diabetes in albino rats, and brought down the level of serum cholesterol and blood urea. This activity is attributed to a glucoside, bengalenoside and the flavonoid glycosides, leucocyanidin and leucopelargonidin. Bengalenoside is half as potent as tolbutamide. The leucopelargonidin glycoside is practically nontoxic and may be useful in controlling diabetes with hyperlipi- demia. The leucocyanidin, when combined with a low dose of insulin, not only equalled in response the effects brought about by a double dose of insulin, but also excelled in amelioration of serum cholesterol and triglycerides.(Additional references: Indian J Physiol Pharmacol, 1975, 19(4), 218220; J Ethnopharmacol, 1989, 26(1), 155; Indian J Physiol Pharmacol, 1994, 38(3), 220-222.)... ficus benghalensisThe Council is funded by doctors’ annual fees and is responsible to the Privy Council. Substantial reforms of the GMC’s structure and functions have been and are still being undertaken to ensure that it operates e?ectively in today’s rapidly evolving medical and social environment. In particular, the Council has strengthened its supervisory and disciplinary functions, and among many changes has proposed the regular revalidation of doctors’ professional abilities on a periodic basis. The Medical Register, maintained by the GMC, is intended to enable the public to identify whom it is safe to approach to obtain medical services. Entry on the Register shows that the doctor holds a recognised primary medical quali?cation and is committed to upholding the profession’s values. Under revalidation requirements being ?nalised, in addition to holding an initial quali?cation, doctors wishing to stay on the Register will have to show their continuing ?tness to practise according to the professional attributes laid down by the GMC.
Once revalidation is fully established, there will be four categories of doctor:
Those on the Register who successfully show their ?tness to practise on a regular basis.
Those whose registration is limited, suspended or removed as a result of the Council’s disciplinary procedures.
Those who do not wish to stay on the Register or retain any links with the GMC.
Those, placed on a supplementary list, who do not wish to stay on the main Register but who want to retain a formal link with the medical profession through the Council. Such doctors will not be able to practise or prescribe.... general medical council (gmc)
Nutritional Profile Energy value (calories per serving): Moderate Protein: Low Fat: Low Saturated fat: Low Cholesterol: None Carbohydrates: High Fiber: Low Sodium: Low Major vitamin contribution: Vitamin A, vitamin C Major mineral contribution: Phosphorus
About the Nutrients in This Food Grapes are high in natural sugars, but even with the skin on they have less than one gram dietary fiber per serving. The most important nutrient in grapes is vitamin C. A serving of 10 green or red Thompson seedless grapes has 5.3 mg vitamin C (7 percent of the R DA for a woman, 6 percent of the R DA for a man). The tart, almost sour flavor of unripened grapes comes from natu- rally occurring malic acid. As grapes ripen, their malic acid content declines while their sugar content rises. R ipe eating grapes are always sweet, but they have no stored starches to convert to sugars so they won’t get sweeter after they are picked.
The Most Nutritious Way to Serve This Food Fresh and ripe.
Buying This Food Look for: Plump, well-colored grapes that are firmly attached to green stems that bend easily and snap back when you let them go. Green grapes should have a slightly yellow tint or a pink blush; red grapes should be deep, dark red or purple. Avoid: Mushy grapes, grapes with wrinkled skin, and grapes that feel sticky. They are all past their prime. So are grapes whose stems are dry and brittle. Characteristics of Different Varieties of Grapes Red grapes Cardinal Large, dark red, available March–August Emperor Large red with seeds. September–March Flame Seedless, medium to large, red. June–August R ibier Large, blue-black, with seeds. July–February Tokay Large, bright red, seeds. August–November Queen Large, bright to dark red, seeds. June–August White grapes Almeria Large, golden. August–October Calmeria Longish, light green. October–February Perlette Green, seedless, compact clusters. May–July Thompson Seedless, green to light gold. June–November Source: The Fresh Approach to Grapes (United Fruit & Vegetable Associat ion, n.d.).
Storing This Food Wrap grapes in a plastic bag and store them in the refrigerator. Do not wash grapes until you are ready to use them.
Preparing This Food To serve fresh grapes, rinse them under running water to remove debris, then drain the grapes and pick off stems and leaves. To peel grapes (for salads), choose Catawba, Concord, Delaware, Niagara, or Scup- pernong, the American varieties known as “slipskin” because the skin comes off easily. The European varieties (emperor, flame, Tokay, Muscat, Thompson) are more of a challenge. To peel them, put the grapes into a colander and submerge it in boiling water for a few seconds, then rinse or plunge them into cold water. The hot water makes cells in the grape’s flesh swell, stretching the skin; the cold bath makes the cells shrink back from the skin which should now come off easily.
What Happens When You Cook This Food See above.
How Other Kinds of Processing Affect This Food Juice. Red grapes are colored with anthocyanin pigments that turn deeper red in acids and blue, purple, or yellowish in basic (alkaline) solutions. As a result, red grape juice will turn brighter red if you mix it with lemon or orange juice. Since metals (which are basic) would also change the color of the juice, the inside of grape juice cans is coated with plastic or enamel to keep the juice from touching the metal. Since 2000, following several deaths attributed to unpasteurized apple juice contaminated with E. coli O157:H7, the FDA has required that all juices sold in the United States be pasteurized to inactivate harmful organ- isms such as bacteria and mold. Wine-making. Grapes are an ideal fruit for wine-making. They have enough sugar to pro- duce a product that is 10 percent alcohol and are acidic enough to keep unwanted micro- organisms from growing during fermentation. Some wines retain some of the nutrients originally present in the grapes from which they are made. (See wine.) Drying. See r aisins.
Medical Uses and/or Benefits Lower risk of cardiovascular disease, diabetes, and some forms of cancer. Grape skin, pulp, and seed contain resveratrol, one of a group of plant chemicals credited with lowering cholesterol and thus reducing the risk of heart attack by preventing molecular fragments called free radicals from linking together to form compounds that damage body cells, leading to blocked arteries (heart disease), glucose-damaged blood vessels (diabetes), and unregulated cell growth (cancer). The juice from purple grapes has more resveratrol than the juice from red grapes, which has more resveratrol than the juice from white grapes. More specifically, in 1998, a team of food scientists from the USDA Agricultural Research Service identified a native American grape, the muscadine, commonly used to make grape juice in the United States, as an unusually potent source of resveratrol.... grapes
Habitat: Throughout warmer parts of India.
Ayurvedic: Tilaparni (white var.), (Pita or yellow-flowered var. is equated with Cleome viscosa Linn.), Ajagandhaa, Pashugandhaa, Ugragandhaa, Puutigandhaa, Barbaraka. Suuryaavartta has been equated with G. pentaphylla DC.Siddha/Tamil: Thaivelai, Nalvelai.Action: Leaves and seeds—used in the same way as mustard. Bruised leaves—rubefacient and vesicant, used as counter-irritant in headache, neuralgia, rheumatic affections. Roots—decoction, febrifuge. Seeds—anthelmintic; externally counter-irritant. Applied as poultice to sores with maggots. An infusion is given for coughs.
The Ayurvedic Pharmacopoeia ofIn- dia recommended the use of the seed in chlorsis, chronic obstructive jaundice and enlarged prostate.The seeds are reported to contain cleomin, hexacosanol, free beta-sitos- terol and kaempferol; also glucosino- lates.Alcoholic extract of the whole plant exhibited anti-inflammatory activity in carrageenan-induced inflammation in rats.The medicinal properties of the seeds are attributed to the presence of cleomin. Seeds also contain 1% tannins.Dosage: Seed—1-3 g powder. (API Vol. I.) Leaf—50-100 ml decoction. (CCRAS.)... gynandropsis gynandraIn hospital the possible need for urgent action is monitored by use of the GLASGOW COMA SCALE.
People suffering the results of such injuries and their relatives can obtain help and advice from Headway – the brain injury association.... head injury
c.460 to 377 BC and who taught students at the medical school in Cos. Often called the ‘father of medicine’, he is renowned for drawing up the HIPPOCRATIC OATH, some of which may have been derived from the ancient oath of the Aesclepiads. Apart from his oath, Hippocrates has about 60 other medical works attributed to him, forming a corpus which was collected around 250 BC in the famous library of Alexandria in Egypt. Hippocratic medicine appealed ‘to reason rather than to rules or to supernatural forces’ is how the late Roy Porter, the English social historian, summed up its ethos in his medical history, The Greatest Bene?t to Mankind (Harper Collins, 1997). Porter also commended Hippocrates as being patient-centred rather than disease-orientated in his practice of medicine.... hippocrates
Habitat: Cultivated as food crop in Uttar Pradesh, West Bengal, Bihar, Madhya Pradesh, Rajasthan, Haryana, Punjab, Himachal Pradesh and Jammu and Kashmir.
English: BarleyAyurvedic: Yava, Hayeshtha, Hayapriya, Shuka-dhaanya, Tiksh- nashuka.Unani: Barley, Jao Shaeer.Siddha: Yavam. Saambaluppu (ash).Action: Barley—nutritive and demulcent during convalescence and in cases of bowel inflammation and diarrhoea. Protects immune system.
The Ayurvedic Pharmacopoeia ofIn- dia recommends barley in urinary disorders, muscular rigidity, chronic sinusitis, cough, asthma, lipid disorder and obesity.Juice of young barley leaves—7 times richer in vitamin C than oranges, 5 times richer in iron than spinach, 25 times richer in potassium than wheat; high in SOD (superoxide dismutase), an enzyme that slows ageing of cells.The nutritional quality of the barley depends on beta-glucan fraction of the grain. Beta-glucan-enriched fraction produced cholesterol-lowering effect in hamsters.Naked barley extracts have been found to selectively inhibit cyclohex- anase activity and may be useful as a therapeutic drug for treating thrombosis and atherosclerosis.Ethanol extract of young green leaves exhibits antioxidant activity attributed to a flavonoid, 2"-O-glucosyl- isovitexin. It also exhibits antiinflammatory and antiallergic activities. The leaves contain an indole alkaloid, gramine, which exhibits antibacterial properties.Dosage: Dried fruit—100-200 g. (API Vol. II); dried plant—10-20 g. (API Vol. IV.)... hordeum vulgareHabitat: Native to Europe; cultivated in gardens. Reported to occur in Chamba.
English: Rocket Candytuft, Clown's Mustard.Action: Used for gout, rheumatism, also for bronchitis and asthma; as a tonic in enlargement of heart to allay excited action of the heart.
The seeds contain a mustard oil and a glycoside, glucoiberin. The plant contains sulphur-containing glucosi- nolates; also contains bitter and toxic tetracycloterpenoids, cucurbitacin E and I.The seed extract exhibited cytotox- icity against renal and brain tumours and melanoma cell lines. The activity may be attributed to the presence of cucurbitacins E and I.... iberis amaraHabitat: Cultivated in plains throughout India.
English: Garden Balsam. (Balsam Apple is not related to Impatiens. It is the fruit of Momordica balsamina.)Ayurvedic: Tarini (provisional synonym).Unani: Gul-menhdi.Siddha/Tamil: Kasittumbai.Action: Cathartic, diuretic, antirheumatic. Flowers—used in burns and scalds.
The plant is reported to contain cyanochroic constituents, antibacterial substances and an alkaloid. The seeds contain the triterpenoid hosenkol A, the first baccharance triterpenoid from natural source. The seeds also contain a protein-associated amyloid, galac- toxyloglucan and beta-sitosterol.In China, the aerial parts are used for the treatment of articular rheumatism. In Korea, the plant is used for treating tuberculosis. In Brunei, a decoction of the root is given in irregular menstruation. In Japan, the juice, obtained from the white petals, is applied topically to treat several types of dermatitis, including urticaria.The flowers contain flavonols, flavo- noid pigments, phenolic compounds and quinones.An ethanolic extract (35%) of flowers shows significant anti-anaphylactic activity in mice.The methanolic extract of the whole plant exhibited strong antibacterial activity against Bacillus subtilis and Salmonella typhimurium; antibacterial and antifungal activity has been attributed to a naphthoquinone derivative.... impatiens balsaminaHabitat: The Himalayas up to 1,200 m and in plains of India.
English: Trailing indigo.Ayurvedic: Vaasukaa.Siddha/Tamil: Cheppunerinjil.Folk: Hanumaan-buuti, Bhui-nila.Action: Juice of the plant— antiscorbutic, diuretic, alterative. The plant, boiled with oil, is applied to burns. A decoction is given in epilepsy and insanity.
The plant contains two unsaturat- ed hydrocarbons—indigoferin and en- neaphyllin. The seeds contain 37.8% protein, also yield lipids (4.4%) containing palmitic and oleic acid. The toxicity of the plant is attributed to a non-protein amino acid, indospicine (6-amidino-2-aminohexanoic acid). (Consumption of the plant produces a neurological syndrome, known as Birdsville disease, in horses. The toxic- ity is greatly reduced when the material is chopped and dried.)The aerial parts gave 3-nitropropa- noyl esters of D-glucose.... indigofera enneaphyllaIntersexuality inevitably leads to considerable psychological disturbance as the child grows up. It is therefore important to reach an early decision as to the child’s sex – or at least, the sex that he or she is to be brought up as. Surgical or hormonal means should then be employed, when appropriate, to develop the attributes of that sex and diminish those of the other, together with psychological counselling.... intersexuality
Habitat: Throughout the plains of India, cultivated in gardens.
Ayurvedic: Sugandha-vachaa, Chandramuula, Chandramuulikaa. (In Kerala, used as Karchura and Shathi.) (Kapurakachari is a different drug, equated with Hedychium spicatum.)Siddha/Tamil: Kachoram.Action: Tuber—stimulant, carminative, expectorant, diuretic used for respiratory ailments like cough, bronchitis and asthma.
The essential oil from rhizomes contain n-pentadecane, ethyl-p-methoxy cinnamate, ethyl cinnamate, carene, camphene, borneol, p-methoxysty- rene, p-methoxy cinnamate, p-meth- oxy-trans-cinnamic acid and cin namaldehyde. Insecticidal activity of the oil is attributed to ethyl cinna- mates. Ethyl-p-methoxy-cinnamate shows monoamine oxidase inhibitor activity and a cytotoxic principle (the rhizomes exhibit cytotoxic activity).Leaves and flowers exhibit antiphlogistic and vitamin P activity. Ethyl-p- methoxy-trans cinnamate is the main compound in the root.... kaempferia galangaHabitat: North-western and Peninsular India.
Folk: Bui-chholi (Punjab). Kauraro.Action: Cardiac stimulant.
Resinous alkaloid, isolated from alcoholic extract of the plant, showed nicotinic action on autonomic ganglion and neuromuscular junction of voluntary muscles.Fruits and leaves of a related sp., K. scoparia Schrad are used as a cardiac tonic and diuretic.Petroleum ether extract of aerial parts contain n-alkanes, free alcohols and a mixture of sterols (mainly sitos- terol, 70.9%).The plant exhibits antibacterial activity which is attributed to hydrocarbons and sterols present in it. The plant is also used as an ingredient of a medicinal powder used for dermatitis.... kochia indicaHabitat: Throughout India, from Punjab and Kumaon eastwards; in Assam, Bihar, Orissa, Madhya Pradesh, Maharashtra, Karnataka and South India.
Ayurvedic: Bilvaparni.Siddha/Tamil: Nayvila.Folk: Ran-limbu, Naringi (Mum- bai), Tondsha (Maharashtra), Beli, Bainthaa.Action: Dried fruit—stomachic; used in pestilent fevers, also as an antidote to poisons. Root— purgative, sudorific.
The plant showed anti-inflammatory activity which was attributed to 8- hydroxy-6-methoxy-2-methyl-anthra- quinone-3-O-beta-D-glucopyranoside in animal studies.The leaves contain an essential oil; major constituents are geraniol, alpha- and beta-pinene, 1,8-cineole, elemol acetate, linool, alpha-terpinolene, camphor, eudesmol, p-cymene, cam- phane, azulene, borneol acetate, alpha- terpenol, alpha-curcumene, alpha thu- jone, limolene, myrcene and beta- ocimene.Leaves also contain anthraquinones and dalbargin galactopyranoside.... limonia crenulataHabitat: Punjab, Rajasthan, Gujarat and Maharashtra.
Unani: Chirchataa, Chirchitaa, Chirchitta.Folk: Kheechar Chirchataa.Action: Immunostimulatory, antiproliferatory, antiageing; antioxidant.
The leaves and flowers contain free quercetin (1.28 and 1.58 mg/g dry weight, respectively), and bound kaem- pferol. Total alkaloid percentage is nearly the same in shoots (1.26%) and fruits (1.24%) but lower in cal- li (0.83%) and roots (0.67%). Fruits had highest atropine content (0.95%) and shoots the highest hyoscyamine content (0.33%).Flavonoids are active against E. coli, Staphylococcus aureus and Candida albicans (quercetin does not show activity against Candida albicans).The polysaccharide extract from fruits showed antiageing, immunos- timulatory and antiproliferatory activities. The polysaccharide acts as an an- tioxidant and prevented CCl4-induced increases in lipid peroxidases in liver. It can also protect against genetic damage from mutagenic and genotoxic compounds. This activity leads to its potential use in preventing the adverse effects of chemotherapeutic agents.The fruit contain beta-carotene (8 mg/100 g dry weight), also free amino acids (1.0-2.6%); major amino acid is proline.The dried fruit and root bark reduce cholesterol level by preventing its absorption in gastrointestinal tract. A constituent of the root bark, kuko- amine exhibits cholesterol lowering, antihypertensive and hypoglycaemic effects. Hepatoprotective activity is attributed to a cerebroside constituent found in the fruit. (Natural Medicines Comprehensive Database, 2007.)The fruit and root bark is contraindi- cated in bleeding disorders and hypoglycemia. (Sharon M. Herr.)... lycium barbarumHabitat: Western Himalayas in Jammu and Kashmir, and Himachal Pradesh.
English: Gipsywort, Bugleweed.Folk: Gandam-gundu, Jalneem.Action: Cardioactive, diuretic, peripheral vasoconstrictor, sedative, narcotic, antihaemorrhagic, antitussive, thyrostatic.
Key application: In mild thyroid hyperfunction (contraindicated in thyroid hypofunction, enlargement of thyroid) with disturbances of vegetative nervous system; masto- dynia (tension and pain in breast). No simultaneous administration of thyroid preparations. Administration of Bugleweed preparations interferes with the administration of diagnostic procedures using radioactive isotopes. (German Commission E.)The leaves contain lithospermic acid. Plant contains luteolin-7-glucoside; ur- solic acid, caffeic acid, chlorogenic acid, sinapic acid, ellagic acid and other derivatives of phenolic acid. The antioxidant activity of the plant is partially attributed to rosmarinic acid. Antigonadotropic activity of the leaf extract is attributed to phenolic precursors.Ethanol extract of the plant showed diverse effects on the pituitary, thyroid and gonadal glands of rats.A closely related species, Lycopus virginicus of Europe, exhibits anti- thyrotropic activity. It induces TSH repletion in hypothyroid rats and reduction of TSH levels in euthyroid rats. Antigonadotropic activity has been demonstrated in rats.... lycopus europaeusHabitat: Mediterranean region.
English: Mandrake.Ayurvedic: Wrongly equated with Lakshmanaa, a fertility promoting herb. (In Indian medicine, Panax quinquefolium Linn. and Panax schinseng Nees have been equated with Lakshmanaa.)Action: Anaesthetic, narcotic, poisonous. Alkaloid pattern similar to Atropa belladona. A sample of roots from Morocco contained atropine (0.2% at flowering stage).
In India, Panax sp. are perceived as fertility and vitality promoting herbs, which have been attributed to Laksh- manaa. Mandrake exhibits anticholinergic effects.English Mandrake and American Mandrake are equated with Bryonia alba and Podophyllum hexandrum respectively.... mandragora autumnalisHabitat: Cultivated and naturalized throuhout India. Wild in the Sub-Himalayan tract up to 1,800 m.
English: Persian Lilac, Pride of India.Ayurvedic: Mahaanimba, Ramyaka, Dreka. (Neem is equated with Azadirachta indica.)Unani: Bakaayan.Siddha/Tamil: Malaivembu.Action: Leaf—diuretic, anthelmintic, antilithic. Leaf and flower—febrifuge, sedative, em- menagogue. Leaf, fruit and stem bark—antileprotic. Leaf, flower, fruit, root bark—deobstruent, resolvent. Seed oil—antirheumatic, insecticidal. Leaves, bark and fruit—insect repellent. Gum— used in spleen enlargement. Heart- wood—an aqueous extract, used in asthma.
The Ayurvedic Pharmacopoeia ofIn- dia indicated the use of the dried stem bark in increased frequency and turbidity of urine, skin diseases, nausea, emesis, asthma, gastroenteritis, giddiness and vertigo.The bitter constituents are present exclusively in the pericarp, not in the kernel as in the case of Neem fruit. Bakayanin has been isolated from the pericarp (bitter in dilutions of 1 in 10,000).The heartwood also yielded bakaya- nin and a lactone, bakalactone. Leaves gave quercitrin and rutin and tetranor- triterpenoids, salanin and vilasinin.An infusion of the bark is effective against ascariasis. The activity resides in the inner bark which is bitter but not astringent (outer bark contains tannins and is astringent).The ethanolic extract of the leaves is fungicidal and antibacterial. The activity is attributed to azadrine and me- liotannic acid.The fruits are considered poisonous to man and animals; contain melianon- inol, melianol, melianone, meliandi- ol, vanillin and vanillic acid. Vanillic acid analogues show micro- and macro-filaricidal activity.Gedunin, present in the plant, inhibits Plasmodium falciparum, while the seed extract does not show anti- malarial activity against P. berghei.The plant exhibited sedative and psychostimulant properties. Antitu- mour and antiviral activities have also been reported. Intraperitoneal administration of partially purified extracts of fresh green leaves reduced the spread of Tacaribe virus (that causes typical encephalitis) to kidneys, liver and brain in inoculated neonatal mice.Dosage: Stem bark—5-10 g (API, Vol. IV.); leaf, seed, root—50- 100 ml decoction; 3-5 g powder. (CCRAS.)... melia azedarachHabitat: Native to Britain and Europe; found in Kashmir.
English: Bogbean, Buckbean, Goat's bean, Marsh Trefoil.Folk: Buckbean.Action: Bitter tonic, deobstruent. Laxative in large doses. Used for diseases of liver and gallbladder, and rheumatism. (Contraindicated in diarrhoea, dysentery and colitis.)
Key application: Leaf—in loss of appetite, peptic discomforts. (German Commission E.) As a bitter tonic. (The British Herbal Pharmacopoeia.) The drug stimulates saliva and gastric juice secretion. (German Commission E.)The herb contains iridoid glyco- sides, foliamenthin, dihydrofoliamen- thin, menthiafolin and loganin; pyri- dine alkaloids including gentianine; coumarins (scopoletin); phenolic acids (caffeic, with protocatechuic, ferulic, sinapic, vanillic including others; fla- vonoids including rutin, hyperoside.Choleretic action of the herb is attributed to the synergistic action of caffeic and ferulic acids and iridoid glycosides.Scoparone and scopoletin (cou- marins isolated from the aerial parts) exhibit antihepatotoxic, choleretic and cholagogue properties.The rhizomes contain dihydrofolia- menthin, loganin, menthiafolin and a triterpenoid saponin menyantho- side. Aqueous extract of the rhizome showed greater preserved renal function and higher glomerular filtration rate, possibly due to Platelet Activating Factor (PAF)-antagonistic effect of the extract.... menyanthes trifoliataHabitat: Native to the Moluccas Islands; grown in the Nilgiris, Kerala, Karnataka and West Bengal.
English: Nutmeg, Mace.Ayurvedic: Jaatiphala, Jaatishasya, Maalatiphala (seed kernel).Jaatipatri, Jaatipatra, Jaatipatraka, Jaatikosha (mace).Unani: Jauzbuwaa (seed), Bisbaasaa (mace).Siddha/Tamil: Jaathikkai, Saadikai (nutmeg); Saadippatthiri, Jaadip- patiri (mace).Action: Nutmeg—carminative, spasmolytic, antiemetic, orexi- genic; topically anti-inflammatory. Mace—stimulant carminative. Narcotic in high doses.
Nutmeg is used in flatulency, diarrhoea, nausea and vomiting. Mace is used in rheumatism, chronic bowel complaints and asthma. When roasted, both nutmeg and mace are used for diarrhoea, colic, flatulence and dyspepsia.Key application: Dried seed and aril—included among unapproved herbs by German Commission E. Following actions have been considered: antispasmodic, MAO inhibition, inhibition of prostaglandin synthesis.The Ayurvedic Pharmacopoeia of India recommends the kernel of the fruit in spermatorrhoea.An aqueous extract of nutmeg is reported to show anti-secretory activity against E. coli heat-labile enterotoxin; the hexane soluble fraction of the alcoholic extract inhibited the heat-labile and heat-stable-enterotoxin-induced secretory response in animal studies.The hexane extract contains myris- ticin, an anti-inflammatory principle, and licarin-B and dehydro di- isoeugenol which exhibited CNS depressant properties. The extracts of nutmeg decreased kidney prostaglan- din levels in rats. They also inhibited platelet aggregation (due to eugenol and isoeugenol). The anti-inflammatory activity observed in carrage- enan-induced oedema in rats and enhanced vascular permeability in mice, are attributed to myristicin present in mace.Mace also activates hepatic detoxification process. Monomeric and dimer- ic phenyl propanoids (myristicin, de- hydro diisoeugenol) from mace, on p.o. administration in mice, produced suppression of lipid peroxidation in liver.Seeds contain about 0.24% myris- ticin, whereas volatile oil about 3.12%.The resorcinols, malabaricones B and C, isolated from the seed coat (mace) exhibited strong antibacterial and antifungal activities. Neoplasm inhibitors, phenylpropyl derivatives, have been isolated from pulverized mace.Dosage: Endosperm of dried seed (kernel of fruit)—0.5-1.0 g powder. (API, Vol. I.)... myristica fragransNearly three-quarters of neonatal deaths occur during the ?rst week of life. For this reason, increasing emphasis is being laid on this initial period of life. In Britain, in the last four decades of the 20th century, the number of deaths in the ?rst week of life fell dramatically from 13.2 to just over 2.7 per 1,000 live births. The chief causes of deaths in this period are extreme prematurity (less than 28 weeks’ gestation), birth asphyxia with oxygen lack to the brain, and congenital abnormalities. After the ?rst week the commonest cause is infection.... neonatal mortality
Habitat: Cultivated in Britain and the USA. Occurs in Himalayas from Kashmir to Nepal at 2,000-3,300 m.
English: Catnip, Catnep, Catmint.Action: Leaves and flowers— gentle nerve relaxant and sedative, carminative, antispasmodic, an- tidiarrhoeal, diaphoretic, febrifuge. Used in restlessness, convulsions, nervous headache, colic, early stages of fever, colds and influenza. The herb is to be infused (not boiled).
Catnip contains iridoids, tannins and volatile oil, major components being alpha- and beta-nepetalactone (up to 42%), citronellol and geraniol.The catnip response in the domestic cat is being attributed to iridoid lac- tones, nepetalactone, dihydronepeta- lactone, iso-dihydronepetalactone and neonepetalactone. Its reputation as a hallucinogen has been disputed, but a few studies have shown behavioural effects, although weak, in young chicks, rodents and cats. (Potter's New Cyclopaedia.)Neptalactone is structurally related to valepotriates found in valerian. (Natural Medicines Comprehensive Database, 2007.)... nepeta catariaHabitat: Evergreen forests of Western India from Khandala southwards to Malabar and Coim- batore.
Ayurvedic: Surapunnaaga (Naa- gakeshara is equated with Mesua ferrea.)Siddha/Tamil: Nagappu, Nagesarpu.Folk: Laal-Naagakeshar. Surangi (Maharashtra).Action: Flowerbuds—cooling, stomachic, analgesic, antibacterial; used for gastritis, haemorrhoids, blood diseases, leprosy, leucoder- ma.
Flower buds are popularly known as Naagakeshar.Flowers exhibited potent hypoten- sive, anti-inflammatory and antispas- modic activity attributed to vitexin.Leaves gave amentoflavone, querce- tin and vitexin as major constituents.... ochrocarpus longifoliusHabitat: Kashmir and Kumaon up to 1,000-1,500 m.
Unani: Ratanjot (equated with Onosma echioides Linn., according to National Formularly ofUnani Medicine).Action: Astringent and styptic. Root—bruised and used as application to eruptions. An ingredient of ointments for ulcers, scrofula, burns. Flowers—stimulant, cardiac tonic.
Ursolic acid and naphthoquinones, onosone A and B have been isolated from the root. Shikonin acetate is obtained from callus cultures of the plant.The species, distributed in western Himalayas, is Onosma echioides C. B. Clarke non Linn.; Onosma echioides Linn. is an European species. A variety of this species, var. kashmiricum Johnson, is found in Kashmir. Onosma hookeri C. B. Clarke occurs in Sikkim and Bhutan.Maharanga emodi (Wall.) DC., synonym Onosma emodi (Wall.) DC. (the Himalayas from Garhwal to Bhutan at altitudes of 3,500-4,000 m) is also known as Ratanjot and Shankhuli.(Ratanjot is used in a generic sense to cover a range of red dye-yielding roots, rather than the root of a single species. As many as 15 plant species belonging to four different families are known as Ratanjot; five of them do not yield red dye. General properties and colour reactions attributed to Ratanjot resemble Alkanet from Alkanna tinctoria Tausch.)... onosma echioidesGrade of obesity
BMI (W/H2) III >40 II 30–40 I 25–29·9 not obese <25
Causes Whatever the causes of obesity, the fact remains that energy intake (in the form of food and drink) must exceed energy output (in the form of activity and exercise) over a suf?ciently long period of time.
Obesity tends to aggregate in families. This has led to the suggestion that some people inherit a ‘thrifty’ gene which predisposes them to obesity in later life by lowering their energy output. Indeed, patients often attribute their obesity to such a metabolic defect. Total energy output is made up of the resting metabolic rate (RMR), which represents about 70 per cent of the total; the energy cost of physical activity; and thermogenesis, i.e. the increase in energy output in response to food intake, cold exposure, some drugs and psychological in?uences. In general, obese people are consistently found to have a higher RMR and total energy output, per person – and also when expressed against fat-free mass – than do their lean counterparts. Most obese people do not appear to have a reduced capacity for thermogenesis. Although a genetic component to obesity remains a possibility, it is unlikely to be great or to prevent weight loss from being possible in most patients by reducing energy intake. Environmental in?uences are believed to be more important in explaining the familial association in obesity.
An inactive lifestyle plays a minor role in the development of obesity, but it is unclear whether people are obese because they are inactive or are inactive because they are obese. For the majority of obese people, the explanation must lie in an excessive energy intake. Unfortunately, it is di?cult to demonstrate this directly since the methods used to assess how much people eat are unreliable. For most obese people it seems likely that the defect lies in their failure to regulate energy intake in response to a variety of cognitive factors (e.g. ease of ?tting of clothes) in the long term.
Unfortunately, it can be possible to identify by the time of their ?rst birthday, many of the children destined to be obese.
Rarely, obesity has an endocrine basis and is caused by hypothyroidism (see under THYROID GLAND, DISEASES OF), HYPOPITUITARISM, HYPOGONADISM or CUSHING’S SYNDROME.
Symptoms Obesity has adverse effects on MORBIDITY and mortality (see DEATH RATE) which are greatest in young adults and increase with the severity of obesity. It is associated with an increased mortality and/or morbidity from cardiovascular disease, non-insulin-dependent diabetes mellitus, diseases of the gall-bladder, osteoarthritis, hernia, gout and possibly certain cancers (i.e. colon, rectum and prostate in men, and breast, ovary, endometrium and cervix in women). Menstrual irregularities and ovulatory failure are often experienced by obese women. Obese people are also at greater risk when they undergo surgery. With the exception of gallstone formation, weight loss will reduce these health risks.
Treatment Creation of an energy de?cit is essential for weight loss to occur, so the initial line of treatment is a slimming diet. An average de?cit of 1,000 kcal/day (see CALORIE) will produce a loss of 1 kg of fat/week and should be aimed for. Theoretically, this can be achieved by increasing energy expenditure or reducing energy intake. In practice, a low-energy diet is the usual form of treatment since attempts to increase energy expenditure, either by physical exercise or a thermogenic drug, are relatively ine?ective.
Anorectic drugs, gastric stapling and jaw-wiring are sometimes used to treat severe obesity. They are said to aid compliance with a low-energy diet by either reducing hunger (anorectic drugs) or limiting the amount of food the patient can eat. Unfortunately, the long-term e?ectiveness of gastric stapling is not known, and it is debatable whether the modest reduction in weight achieved by use of anorectic drugs is worthwhile – although a new drug, ORLISTAT, is becoming available that reduces the amount of fat absorbed from food in the gastrointestinal tract. For some grossly obese patients, jaw-wiring can be helpful, but a regain of weight once the wires are removed must be prevented. These procedures carry a risk, so should be done only if an individual’s health is in danger.... obesity
Habitat: Native to tropical America; cultivated in Indian gardens in Uttar Pradesh and Tamil Nadu; also grows in moist places as a weed.
Action: Plant—diuretic.
salin B and F have been isolated from the ethanolic extract of the whole plant. Both physalin B and F are reported to inhibit the growth of several human leukaemia cell systems.Aerial parts yielded seco-withano- lides—cleaved steroidal constituents containing physalins. In Taiwan, phy-Family: Solanaceae.Habitat: Throughout India, ascending up to 2,300 m.
English: Sun-berry.Ayurvedic: Tankaari, Parpotikaa, Chirapotikaa.Siddha/Tamil: Sodakku thakkali.Action: Berries—diuretic, aperient, alterative. Used for gout and urinary diseases.
Quercetin 3-O-galactoside, isolated from the crude extract of the leaves, is reported to exhibit anti-inflammatory activity comparable to phenylbutazone in carageenan-induced rat paw oedema.Physalis minima Linn. var indica C. B. Clarke is common weed in irrigated fields and bunds.The plant contains withasteroids, physalindicanols, withaminimin and withaphysalin, 3-O-glucosides of kaempferol and quercetin, in addition to beta-sitosterol and its glucoside.The diuretic action of Physalis minima leaves is attributed to the high content of potassium nitrate (8-10%).... physalis angulataHabitat: Cultivated in warmer and damper parts of India; Assam, West Bengal, Bihar, Uttar Pradesh, Karnataka, Kerala.
English: Betel pepper.Ayurvedic: Taambula, Naagvallari, Naagini, Taambulvalli, Saptashiraa, Bhujangalataa.Unani: Paan, Tambool.Siddha/Tamil: Vetrilai Nagavalli, Kammaaruvetritai.Action: Leaf—stimulant, carminative, astringent, antiseptic. Essential oil from leaves—antispasmodic, antiseptic. Used in respiratory catarrhs. Fruit—bechic.
The leaves afforded beta- and gam- ma-sitosterol, hentriacontane, pen- tatriacontane, n-triacontanol, stearic acid and chavicol. The essential oil from leaves contained carvacrol, euge- nol, chavicol, allyl catechol, cineole, estragol, caryophyllene, cardinene, p- cymene and eugenol methyl ether.Administration of the leaf extract resulted in decreased tumour burden and tumour incidence and a delay in the onset of mammary tumour in Wistar rats.The alcoholic extract of the leaf stalk is reported to show antispermatogenic and antiandrogenic effect in male albino rats.The essential oil exhibited hypoten- sive, cardiac as well as respiratory depressant and cardiotonic properties.The leaf showed antifungal and antibacterial activity. The antiseptic activity is attributed to chavicol.Dosage: Leaf—10-15 ml juice. (API, Vol. III.)... piper betleHabitat: Subtropical Himalayas, Ganjam, Konkan, Western Ghats and the Nilgiris.
Siddha/Tamil: Kattu Sampangi.Folk: Tumari. Vikhaari, Vekhali (Maharashtra).Action: Bark—anti-inflammatory, antispasmodic, narcotic; used in chronic bronchitis; also administered in leprous affections; a paste is applied to inflammatory and rheumatic swellings.
The Himalayan plants yielded an essential oil (0.26%) with alpha-pinene, dipentene, linalool, cineol, methyl sal- icylate, decyl aldehyde, anisaldehyde, bergapten, eugenol, indole and salicylic and benzoic acids as major constituents. The oil is applied topically in sprains, bruises, sciatica, rheumatism, chest affections and in certain skin diseases.The narcotic action of the bark is attributed to the presence of a yellow oleoresin. The bark also contain a saponin, pittosporin.... pittosporum floribundumHabitat: Western Himalayas, from Kashmir to Garhwal and Simla.
English: Rib Grass, Ribwort Plantain, English Plantain, Buckhorn Plantain.Unani: Baartang, Aspaghol.Folk: Balatang.Action: Leaf and root—astringent, bechic, antiasthmatic, anti-inflammatory, hypothermic, diuretic. Seed—cathartic, diuretic, haemostatic.
Key application: Internally, for catarrhs of the respiratory tract and inflammatory alterations of the oral and pharyngeal mucosa; externally for inflammatory reactions of the skin. (German Commission E, ESCOP.)Globularin and methyl ester of de- sacetyl asperulosidic acid were isolated from the plant along with cat- apol. A crude mucilage, isolated from the leaves, contains L-arabinose 26.0, D-galactose 35.8, D-glucose 21.9, D- mannose 4.6, L-rhamnose 4.6 and uronic acid 6.9%. Alpha-D-glucan was separated from this mucilage.Leaves gave aucubin and esculetin, in addition to polysaccharides. The whole plant yielded rhamnosidoglyco- side of caffeic acid. Seeds contain 1.1% aucubin. Aucubin exhibits antibacterial activity. Hepatoprotective effect is also attributed to the aucubin content.Alcoholic extract of young leaves exhibit antibacterial action against Streptococcus betahaemolyticus, Micrococ- cus pyogenes var. aureus and Bacillus subtilis, thus confirming their wound- healing properties.... plantago lanceolataHabitat: From Kashmir to Kumaon.
English: Knotgrass, Knotweed, Mexican Sanguinaria.Folk: Machoti, Kesri.Action: Astringent and haemostatic. Used for excessive menstruation, bleeding piles; bleeding from bowel, stomach, lungs, nose, throat; mucous colitis, children's summer diarrhoea.
Key application: In mild catarrhs of the respiratory tract, inflammatory changes to the oral and pharyngeal mucosa. (German Commission E.)The plant gave flavonoids including quercetin, avicularin, quercitrin, and derivatives of kaempferol, esculetin and scopoletin. The plant also gave gallic, caffeic, oxalic., silicic, chloro- genic and p-coumaric acids; tannins including catechin.The methanolic extract of the plant showed high protection against CCl4- induced hepatotoxicity in mice. This activity is attributed to the presence of flavonoid glucosides.The flavonoids exhibit astringent properties and are found to decrease capillary fragility and have a cortisonelike-effect on gingival tissue. (J Ethno- pharmacol, 74(1), 2001.)... polygonum aviculare
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